Subject: Re: 2-CB and Zoloft or Prozac
Date: Sun, 07 Dec 1997 12:32:02
From: bobw@promind.com (Bob Wallace)
Newsgroups: alt.drugs.chemistry

> I have personal experience with a very similar issue.
> 3,4-dimethoxy-phenethylamine is just one methoxy short of mescaline.
> Reports (by A. Shulgin, I believe, and others) state that this compound 
> is either not active or only very weakly so, even in very large amounts.  
> I wondered if this might be due to rapid metabolism by MAO, and tried 
> taking this drug after taking 25mg of Deprenyl. In fact it was then active.  
> I experienced a mild psychedelic effect including emotional intensification,
> and mild color visuals when I was in a dark environment. I think the dose
> was about 500mg.  I did this twice and had similar reactions both times.  
> I wonder if a higher dose of Deprenyl or a mixed MAOA/MAOB inhibitor
> would have had a greater potentiating effect.

Very interesting report! Phenethylamines tend to be metabolized by MAOB
(and tryptamines by MAOA, though each can work on the other). Deprenyl
is an MAOB inhibitor in smaller doses (up to 10 mg/day), but also inhibits
MAOA in larger doses. I would guess your 25 mg inhibited both MAOA/B
as much as possible, so I don't think a higher dose would make a difference.

- Bob Wallace (just my opinion); bobw@promind.com