University of California - MSDS System PAGE 1
06/27/97
Source of MSDS: FISHER SCIENTIFIC CORPORATION
MATERIAL SAFETY DATA SHEET
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FISHER SCIENTIFIC EMERGENCY NUMBER USA: (201) 796-7100
CHEMICAL DIVISION CHEMTREC ASSISTANCE: (800) 424-9300
1 REAGENT LANE CANADA: (613) 226-8874
FAIR LAWN, NJ 07410
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SUBSTANCE IDENTIFICATION
CAS NUMBER: 58-08-2
RTECS NUMBER: EV6475000
SUBSTANCE: **CAFFEINE**
TRADE NAMES/SYNONYMS:
1H-PURINE-2,6-DIONE, 3,7-DIHYDRO-1,3,7-TRIMETHYL-;
1H-PURINE-2,6-DIONE,3,7-DIHYDRO-1,3,7-TRIMETHYL-, THEINE;
3,7-DIHYDRO-1,3,7-TRIMETHYL-1H-PURINE-2,6-DIONE;
1,3,7-TRIMETHYL-2,6-DIOXOPURINE; 1,3,7-TRIMETHYLXANTHINE; TRIMETHYLXANTHINE;
7-METHYLTHEOPHYLLINE; METHYLTHEOBROMINE; ALERT-PEP; CAFEINA; CAFFEIN;
CATIPEL; GUARANINE; KOFFEIN; MATEINA; NO-DOZ; REFRESH'N; STIM; THEIN;
C8H10N4O2;
CHEMICAL FAMILY:
Alkaloid
MOLECULAR FORMULA: C8-H10-N4-O2
MOLECULAR WEIGHT: 194.19
CERCLA RATINGS (SCALE 0-3): HEALTH=3 FIRE=1 REACTIVITY=0 PERSISTENCE=1
NFPA RATINGS (SCALE 0-4): HEALTH=2 FIRE=1 REACTIVITY=0
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COMPONENTS AND CONTAMINANTS
COMPONENT: CAFFEINE PERCENT: 100.0
CAS# 58-08-2
OTHER CONTAMINANTS: NONE.
EXPOSURE LIMITS:
No occupational exposure limits established by OSHA, ACGIH, or NIOSH.
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PHYSICAL DATA
DESCRIPTION: Odorless, white, fleecy masses, glistening needles or powder with
a bitter taste. BOILING POINT: 352 F (178 C) (sublimes)
MELTING POINT: 460 F (238 C) SPECIFIC GRAVITY: 1.2 VOLATILITY: 0.5%
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VAPOR PRESSURE: 760 mmHg @ 178 C PH: 6.9 (1% solution)
SOLUBILITY IN WATER: 2.17% VAPOR DENSITY: 6.7
SOLVENT SOLUBILITY: Soluble in ethyl acetate, chloroform, pyrimidine,
pyrrole, tetrahydrofuran solution; moderately soluble i alcohol, accetone;
slightly soluble in petroleum ether, ether, benzene.
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FIRE AND EXPLOSION DATA
FIRE AND EXPLOSION HAZARD:
Slight fire hazard when exposed to heat or flame.
Dust-air mixtures may ignite or explode.
AUTOIGNITION TEMP.: 1697 F (925 C)
FIREFIGHTING MEDIA:
Dry chemical, carbon dioxide, water spray or regular foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
For larger fires, use water spray, fog or regular foam
(1993 Emergency Response Guidebook, RSPA P 5800.6).
FIREFIGHTING:
Move container from fire area if you can do it without risk (1993 Emergency
Response Guidebook, RSPA P 5800.6, Guide Page 53).
Extinguish using agent suitable for type of surrounding fire. Avoid breathing
vapors and dusts. Keep upwind.
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TRANSPORTATION DATA
U.S. DEPARTMENT OF TRANSPORTATION SHIPPING NAME-ID NUMBER, 49 CFR 172.101:
Poisonous solids, n.o.s.(caffeine)-UN 2811
U.S. DEPARTMENT OF TRANSPORTATION HAZARD CLASS OR DIVISION, 49 CFR 172.101:
6.1 - Poisonous materials
U.S. DEPARTMENT OF TRANSPORTATION PACKING GROUP, 49 CFR 172.101:
PG III
U.S. DEPARTMENT OF TRANSPORTATION LABELING REQUIREMENTS, 49 CFR 172.101
AND SUBPART E:
Keep away from food
U.S. DEPARTMENT OF TRANSPORTATION PACKAGING AUTHORIZATIONS:
EXCEPTIONS: 49 CFR 173.153
NON-BULK PACKAGING: 49 CFR 173.213
BULK PACKAGING: 49 CFR 173.240
U.S. DEPARTMENT OF TRANSPORTATION QUANTITY LIMITATIONS 49 CFR 172.101:
PASSENGER AIRCRAFT OR RAILCAR: 100 kg
CARGO AIRCRAFT ONLY: 200 kg
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TOXICITY
CAFFEINE:
TOXICITY DATA:
ANHYDROUS: 320 mg/kg oral-child LDLo; 192 mg/kg oral-human LDLo;
14700 ug/kg oral-infant TDLo; 13 mg/kg oral-man TDLo; 96 mg/kg/1 day
intermittent oral-woman TDLo; 1 gm/kg oral-woman LDLo; 192 mg/kg oral-rat
LD50; 127 mg/kg oral-mouse LD50; 224 mg/kg oral-rabbit LD50; 100 mg/kg
oral-cat LDLo; 140 mg/kg oral-dog LD50; 230 mg/kg oral-guinea pig LD50;
230 mg/kg oral-hamster LD50; 170 mg/kg subcutaneous-rat LD50; 242 mg/kg
subcutaneous-mouse LD50; 275 mg/kg subcutaneous-rabbit LDLo; 7 mg/kg
intravenous-human TDLo; 57 mg/kg intravenous-woman LDLo; 68 mg/kg
intravenous-infant TDLo; 105 mg/kg intravenous-rat LD50; 62 mg/kg
intravenous-mouse LD50; 58 mg/kg intravenous-rabbit LD50; 240 mg/kg
intraperitoneal-rat LD50; mutagenic data (RTECS); reproductive effects
data (RTECS); tumorigenic data (RTECS).
MONOHYDRATE: No data available.
CARCINOGEN STATUS: Human Inadequate Evidence, Animal Inadequate Evidence (IARC
Group-3).
ACUTE TOXICITY LEVEL: Toxic by ingestion.
TARGET EFFECTS: Poisoning may affect the central nervous system and heart.
AT INCREASED RISK FROM EXPOSURE: Persons with glaucoma, duodenal ulcers,
liver, cardiovascular, renal or psychological disorders.
ADDITIONAL DATA: May cross the placenta. May be excreted in breast milk.
Alcohol may enhance the toxic effects. Interactions with medications have
been reported.
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HEALTH EFFECTS AND FIRST AID
INHALATION:
CAFFEINE:
ACUTE EXPOSURE- May irritate the nose and throat and cause coughing and
chest discomfort. If sufficient quantities are absorbed, may cause
poisoning as detailed in acute ingestion. No deaths were reported in
rats exposed to 55 ppm for 4 hours.
CHRONIC EXPOSURE- If sufficient quantities are absorbed, may cause poisoning
as detailed in chronic ingestion.
FIRST AID- Remove from exposure area to fresh air immediately. Perform
artificial respiration if necessary. Keep person warm and at rest. Treat
symptomatically and supportively. Get medical attention immediately.
SKIN CONTACT:
CAFFEINE:
ACUTE EXPOSURE- May cause irritation.
CHRONIC EXPOSURE- No data available.
FIRST AID- Remove contaminated clothing and shoes immediately. Wash with
soap or mild detergent and large amounts of water until no evidence of
chemical remains (at least 15-20 minutes). Get medical attention
immediately.
EYE CONTACT:
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CAFFEINE:
ACUTE EXPOSURE- May cause irritation.
CHRONIC EXPOSURE- No data available.
FIRST AID- Wash eyes immediately with large amounts of water or normal saline,
occasionally lifting upper and lower lids, until no evidence of chemical
remains (at least 15-20 minutes). Get medical attention immediately.
INGESTION:
CAFFEINE:
TOXIC.
ACUTE EXPOSURE- Low concentrations may cause a small decrease in heart rate.
Ingestion of large amounts may result in headache, lightheadedness,
dizziness, chills, fever, excitement, restlessness, nervousness, insomnia,
mild delirium, hallucinations, tinnitus, constricted pupils, decreased
visual fields, amblyopia, diplopia, photophobia, and scintillating
scotoma. Neurologic symptoms may persist for several days. May cause
gastrointestinal irritation, nausea, vomiting, stimulation of gastric
acid secretion, anorexia, hematemesis, abdominal cramps, diarrhea, and
diuresis followed by oliguria and dehydration. Other effects may include
alternating states of consciousness and muscle twitching, tremors,
hyperesthesia, hypertonicity or hypotonicity, trismus, opisthotonus and
convulsions. Slight increase in basal metabolic rate, metabolic acidosis,
ketonuria, glycosuria, hyperglycemia, hypokalemia and rhabdomyolysis
have been reported. Other effects may include dyspnea, tachypnea, chest
tightness, palpitations, increase in systolic blood pressure, and
arrhythmias including tachycardia and extrasystoles. Seizures generally
precede death.
CHRONIC EXPOSURE- In addition to the effects detailed in acute exposure,
agitation, disturbed sleep, caffeine-induced psychosis, heartburn and
hyperventilation may occur. Low grade fever and elevated plasma free
fatty acid have been reported. Respiratory failure and cardiopulmonary
arrest may occur. Prolonged use of high doses may result in tolerence,
physical and psychological dependence. Symptoms of withdrawal may occur
following abrupt cessation. Use of caffeine by pregnant women has been
associated with increased incidences of spontaneous abortion, breech
presentations, stillbirth, premature delivery, low birth weight,
developmental abnormalities of the craniofacial and musculoskeletal
systems and babies with decreased activity and decreased muscle tone.
Other reproductive effects have been reported in animals. As evaluated by
RTECS, administration to mice resulted in a statistically significant
increase in the incidence of carcinogenic tumors of the skin and
appendages.
FIRST AID- If the person is conscious and not convulsing, induce emesis by
giving syrup of ipecac followed by water or by gastric lavage using
activated charcoal whether or not vomiting has occurred. (If vomiting
occurs keep the head below the hips to prevent aspiration). (Dreisbach,
Handbook of Poisoning, 12th Ed.). Treat symptomatically and supportively.
Gastric lavage should be performed by qualified medical personnel. Get
medical attention immediately.
ANTIDOTE:
No specific antidote. Treat symptomatically and supportively.
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REACTIVITY
REACTIVITY:
Stable under normal temperatures and pressures.
INCOMPATIBILITIES:
CAFFEINE:
ACIDS (STRONG): Incompatible.
BASES (STRONG): Incompatible.
CHLORINE WATER: Incompatible.
OXIDIZERS (STRONG): Fire and explosion hazard.
DECOMPOSITION:
Thermal decomposition products may include toxic oxides of carbon and
nitrogen.
POLYMERIZATION:
Hazardous polymerization has not been reported to occur under normal
temperatures and pressures.
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STORAGE AND DISPOSAL
Observe all federal, state and local regulations when storing or disposing
of this substance.
**Storage**
Store in a tightly closed container.
Store away from incompatible substances.
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CONDITIONS TO AVOID
May burn but does not ignite readily. Prevent dispersion of dust in air. Do
not allow spilled material to contaminate water sources.
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SPILL AND LEAK PROCEDURES
OCCUPATIONAL SPILL:
Do not touch spilled material. Stop leak if you can do it without risk. For
small spills, take up with sand or other absorbent material and place into
containers for later disposal. For small dry spills, with a clean shovel
place material into clean, dry container and cover. Move containers from
spill area. For larger spills, dike far ahead of spill for later disposal.
Keep unnecessary people away. Isolate hazard area and deny entry.
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PROTECTIVE EQUIPMENT
VENTILATION:
Provide local exhaust or process enclosure ventilation. Ventilation equipment
should be explosion-proof if explosive concentrations of dust, vapor or fume
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are present.
RESPIRATOR:
The following respirators are recommended based on information found in the
physical data, toxicity and health effects sections. They are ranked in
order from minimum to maximum respiratory protection.
The specific respirator selected must be based on contamination levels found
in the work place, must be based on the specific operation, must not exceed
the working limits of the respirator and must be jointly approved by the
National Institute for Occupational Safety and Health and the Mine Safety
and Health Administration (NIOSH-MSHA).
Any dust and mist respirator.
Any air-purifying respirator with a high-efficiency particulate filter.
Any powered air-purifying respirator with a dust and mist filter.
Any powered air-purifying respirator with a high-efficiency particulate
filter.
Any type 'C' supplied-air respirator operated in the pressure-demand or
other positive pressure or continuous-flow mode.
Any self-contained breathing apparatus.
FOR FIREFIGHTING AND OTHER IMMEDIATELY DANGEROUS TO LIFE OR HEALTH CONDITIONS:
Any self-contained breathing apparatus that has a full facepiece and is
operated in a pressure-demand or other positive-pressure mode.
Any supplied-air respirator that has a full facepiece and is operated in a
pressure-demand or other positive-pressure mode in combination with an
auxiliary self-contained breathing apparatus operated in pressure-demand
or other positive-pressure mode.
CLOTHING:
Employee must wear appropriate protective (impervious) clothing and equipment
to prevent any possibility of skin contact with this substance.
GLOVES:
Employee must wear appropriate protective gloves to prevent contact with this
substance.
EYE PROTECTION:
Employee must wear splash-proof or dust-resistant safety goggles and a
faceshield to prevent contact with this substance.
Emergency wash facilities:
Where there is any possibility that an employee's eyes and/or skin may be
exposed to this substance, the employer should provide an eye wash fountain
and quick drench shower within the immediate work area for emergency use.
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University of California - MSDS System PAGE 7
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CREATION DATE: 11/21/84 REVISION DATE: 06/07/95
-ADDITIONAL INFORMATION-
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