NBOMe Compounds
Bits & Pieces
The "Bits & Pieces" section is intended for random snippets of information which don't fit
easily elsewhere and/or which have been newly added, but not yet carefully categorized.
easily elsewhere and/or which have been newly added, but not yet carefully categorized.
- Cyclodextrin (HPBCD) Comments from the EMCDDA : 2012 #The EMCDDA has noted that some of the most potent new psychoactive substances, such as the phenethylamines substituted with the "-NBOMe" group (section 3.1.2) and fentanyls, are being offered for sale online as cyclodextrin complexes.
Cyclodextrin complexes are large synthetic molecules produced from starch. They have many legitimate applications including as potential drug delivery methods. This is because they form so-called "host-guest complexes", where a drug molecule can be chemically bound to the cyclodextrin but then released on ingestion. Such a mechanism of action could have benefits for producers, distributors and users of particularly potent new psychoactive substances as it would render them easier and safer to handle. On the other hand, the use of cyclodextrin complexes as a vehicle to carry drugs may have implications for the identification of new substances using established detection techniques. Furthermore, it is possible that this mode of delivery may also increase the capacity for further spread of these 'difficult to handle' drugs. - NBOMe Naming Conventions #When Ralf Heim first published about the NBOMe compounds, they did not have have a consistent, regular naming scheme. When the Nichols lab studied variations of 2,4- and 2,5-dimethoxy (with and without 4-halogen substitution) N-benzyl phenethylamine derivatives, they came up with the "25I-NBOMe" nomenclature in order to keep them all straight.
There are two primary nomenclatures used for the NBOMe compounds. If one followed the naming model used by Alexander Shulgin, 25I-NBOMe and 25B-NBOMe would be called "2C-I-NBOMe" and 2C-B-NBOMe. However, after a media report of a 25I-NBOMe-related fatality erroneously attributed the death to the parent compound "2C-I", we chose to regularize all mentions to the alternate "25I-NBOMe". Hopefully this heads off the tendency by users, reporters, and law enforcement alike to shorten the names inappropriately.