DOSE: T+ 0:00	750 ug	insufflated	25I-NBOMe	(liquid)
T+ 2:00	570 ug	insufflated	25I-NBOMe	(liquid)
T+ 3:15		smoked	Cannabis	(plant material)
T+ 3:30	420 ug	insufflated	25I-NBOMe	(liquid)
T+ 5:15	420 ug	insufflated	25I-NBOMe	(liquid)
T+ 5:30	145 mg	oral	MDMA	(powder / crystals)
T+ 7:00		vaporized	Cannabis	(extract)
T+ 7:30	75 mg	oral	Methoxetamine

BODY WEIGHT:

180 lb

I had done extensive research on 25i before consuming. This is an experimental drug used for scientific research on serotonin (because of its ultra-potency and selectivity) and has a very narrow therapeutic index as evidenced by the number of deaths and hospitalizations on this stuff. I always try to practice harm reduction, and make sure my measured dosages are spot on. Hospitalizations have happened with this stuff in even mild overdoses!

Note that there is a decent amount of polydrug use here. Using drug combinations is not always the safest. I have candyflipped (LSD+MDMA) a number of times before, so I felt safe to do this, but your mileage may vary. Know thy body's limits!

I had 50mg of 25i powder (in the HCL form), and given the fact that I only had a fairly inaccurate 0.001 mg scale, I decided to do a volumetric liquid measurement, probably the most fool proof method of measuring the substance. To 20mg of the powder, in a small glass vial, I added 0.5 ml of 180 proof alcohol and 6.5 ml of water. This is about 2.8mg/1 ml, or about 718 mcg/0.25 ml. This amount of alcohol and water was enough to dissolve the 25i (it was a bit cloudy at the end, but I did not see any precipitate out, I shook the vial everytime I dosed just in case), while the doses taken (0.15-0.25 ml) was not enough liquid nor alcohol to burn the nose bridge much. If I had a reliable way of measuring less than 20mg of the stuff, I would have, and used slightly more alcohol and less water.

Environment: at my apartment, fairly stress free day. Good night's rest before, ate a light meal right before. About 6 days from a ~300mcg LSD trip, so perhaps some cross tolerance existed, but I've used LSD plenty dosing a week apart very successfully, so I wouldn't think there was very much initial cross-tolerance.

T-00: I started out with a 0.25ml (~750mcg) dose, split between two nostrils dosed using an insulin syringe. Mild burn at best from the ethanol content of the liquid. I went to poo right after dosing, and the effects started kicking in about 5 minutes. I felt the wallpaper and bathroom tiles moving around. The stuff came up quick.

I almost felt it was too much right then an there, but I believe most of my fear was from trepidation about the drug. Still, the first 20-30 minutes felt like quite a mind scramble. After having a small coughing storm, and blowing out all my nasal mucosa in a desperate effort to avoid any more 25i entering my blood stream, I started calming down somewhat, and I understood that I had in fact, taken a dose that I could handle and would not send me to the hospital.

After T+1:00, I was in a much better mindstate, and I started enjoying myself quite a bit more. I went to my balcony and enjoyed watching nature. The trees outside were a beautiful combination of green and burnt orange, and I knew autumn was going to arrive soon.

After T+1:30, I felt the full effects. I went from believing it was too high of a dose, to a feeling that I had taken too light of a dose, and felt like redosing to see where that would take me. I saw a lot of OEVs, and tryptamine-like warping of shapes. Music was enhanced, and I watched Magnolia and heard it's soundtrack (good movie while on psychedelics). Still, unlike most of the trips with select other psychedelics like LSD, I did not feel a deep emotional connection with the world nor humanity. It might just have been my mindstate however. I ended up masturbating to some porn during that time, and the erotic felt accentuated, but the actual orgasm felt fairly dull, which is a similar feeling to the same feeling I get under LSD.

At T+2:00, I redosed 0.20ml (~570mcg of 25i). Within minutes, sent me flying high again. Laughing was greatly accentuated. When I looked at myself at a mirror, I had a cheek to cheek huge smile. Faces on the TV were muddled, and I noticed actresses with gobs of makeup, and I thought British accents were somehow hilarious.

At T+3:15, I took a few large hits of good grade BHO vaporized from a chillum. This is a dose that usually does not leave me couchlocked or anything, but mildly stoned. I didn't feel much from the cannabis.

At T+3:30, I redosed 0.15ml (~420mg of 25i). It started hitting again, but it seemed to only prolong the effects, but not greatly intensify it (probably a large amount of tolerance kicking in by then). Still, it was enough to leave me a in a more primitive shamanistic state of mind at times. There wasn't very much of a body load, in fact, I felt great doing a few phsyical things like simple pullups. Overall, I felt less euphoria than with LSD, but felt a few moments of great happiness.

At T+5:00, by this time, I was still seeing some mild hallucinations, but my head and body felt very clear otherwise. I felt like I could have driven a few blocks to the store to grab some food if I wanted to, but thought better of it since I wasn't 100% there. Cracked the only item of food that I had at my place, some protein powder, and ate it dry directly from the tub. Stuffed it in my face; it was very pleasant, but more pleasant was watching it come streaming out my mouth as I opened up my mouth as the wind was blowing outside. Felt exquisite.

At T+5:15, I used my last 25i dose, another 0.15 ml (~420mcg). Came up in minutes again, but I could tell with each dose, it was getting weaker and weaker due to tolerance. Next time, I would have used a slightly stronger dose right up, and not redosed so many times.

At T+5:30, I decided to eat some MDMA crystals. Originally, I was going to do 85mg, but did 145mg instead since I could feel the 25i trip was nowhere near as strong as it was a few hours ago. I was past the peak, despite the redosing.

By T+6:00, I could feel the MDMA take over from the 25i. Felt very energetic more so than emphatic, and I even cleaned up around my apartment in a stimulant-like event. Music felt great. Vision was slightly hazy and colors were a bit altered, maybe a slight shade of blue which I found curious, and I'm sure was due to some neurotransmitter soup.

At T+7:00, vaped some more cannabis oil. Was enough to typically make me fairly stoned and couchlocked, but the MDMA left me way too energized for that. Did not see much of the way of 25i-induced hallucinations at all anymore. I think the Cannabis helped take the edge of the MDMA somewhat.

At T+7:30, I ingested ~75mg of MXE. This was what I considered a medium dose of MXE for me, due to previous tolerance.

By T+8:30, I could feel the MXE really taking over my mind from the MDMA. I had not used MXE in a while, so perhaps a lot of my tolerance was gone, and the 75 mg oral dose was much greater than I expected. I had classic dissociative symptoms. Walking around felt very mechanical. Vision was very skewed, even looking at my own face in the mirror. I lost sense of who I really was, where I was, and what reality was. I've experienced all of this under heavier doses of MXE before.

By T+11, in still a fairly intoxicated MXE-induced state, I fell asleep.

At T+18 - felt great, slightly tired at wakeup but fine after food, slight afterglow for the rest of the day.

Overall, it was a positive experience, but I thought it lacked a bit of what LSD has, with a poorer safety record. I would try a larger initial dose (1.0-1.25mg) with less redoses next time, and see what 25i can teach me.

Exp Year: 2013	ExpID: 101275
Gender: Male
Age at time of experience: 28
Published: Oct 18, 2019	Views: 1,070
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25I-NBOMe (542), MDMA (3), Methoxetamine (527) : Combinations (3), Hangover / Days After (46), Alone (16)