DOSE: T+ 0:00	38 mg	oral	4-HO-MET
T+ 0:00	7.5 mg	oral	Noopept
T+ 3:00	15 mg	oral	4-HO-MET
T+ 3:00	20 mg	oral	Noopept
T+ 8:00	1 mg	oral	Pharms - Alprazolam

BODY WEIGHT:

155 lb

4-HO-MET & Noopept: a Potentiation/Synergy Analysis

As some may know racetams interact synergistically with psychedelics, although the exact nature of this interaction isn't well documented and seems to be somewhat subjective in nature. I'd like to emphasize that the below is framed within my personal subjective experience, which I would expect to be materially consistent across all 4-sub Tryptamines for myself.

Background

I chose 4-HO-MET specifically as a baseline because I've had multiple recent experiences with the compound. One of those trip reports was posted previously [on Reddit and/or elsewhere], however following that experience I conducted another experiment without any additional altering compounds (30mg 4-HO-MET, two weeks ago, no other substances involved).

Following that trip I had a very good sense of the compound's baseline profile, both in standalone and in combination with stimulants/alcohol/DMT at varying timeframes. This gave me a wide array of interactions to use for comparison purposes and made 4-HO-MET the best psychedelic to assess Noopept's possible influence on the overall experience.

Setting, Timeline, & Dosage

Setting: An Expansive Park/Nature Reserve

Last Trip: 2 Weeks Prior, 30mg 4-HO-MET

Timeline/Dosage:

Time Substance Dose ROA
+0:00 4-HO-MET 38.0mg Oral
+0:00 Noopept 7.5mg Oral
+3:00 4-HO-MET 15.0mg Oral
+3:00 Noopept 20.0mg Oral
+8:00 Alprazolam 1.0mg Oral

Summary

+0:00 - For my initial dose I chose to supplement with a small amount of Noopept, the starting dose was larger than previous single doses but not larger (in aggregate) than previous experiences. I went very light with Noopept to err on the side of caution. I reasoned that diving immediately into the combination without starting slowly could yield an unpleasant experience.

+1:30 - Once I settled into the trip I noticed a distinguishably different headspace and visual field than previous experiences with 4-HO-MET. Even at the larger initial dosage I was materially functional and present, the crowded park did not prove to be anxiety inducing or overwhelming. Although the initial dose was on the smaller side for non-sublingual administration of Noopet, I felt part of this reduction in anxiety could definitely be attributed to the addition of Noopept.

The visual intensity at this level was moderate-to-high, but not exceedingly so. It seemed that color enhancement and visual acuity were potentiated by the Noopept, both of which seemed to differ from my baseline experience. Alterations in perception seemed amplified in clarity, having a perceived "sharpness" and reduction in visual haze.

At this point however, I wasn't sure without reasonable doubt that the effects described above could be attributed to the addition of Noopept and considered the the possibility of either a placebo-type effect or simply a change in experiential perception due to setting/the initial higher dosage. I decided to enjoy the ride and wait until I had substantial 4-HO-MET tolerance build-up to pursue further investigation. In my experience redosing past the 2-hour mark is typically lackluster and thus far I had no noticeable negative reactions to the addition of Noopept.

+3:00 - At the three hour mark I dosed 15mg of 4-HO, simply to lengthen the trip (in previous experience +15mg even at +1:30 did not raise intensity much) along with a proper dose of 20mg oral Noopept. Without any potentiators Metocin typically only lasts around 4-5 hours personally, so any noticeable differences in the following period could reliably be associated with the addition of Noopept.

+4:00 - I started to notice a considerable increase from baseline and decided to move locations to a park bench in a quieter area of the park, more akin to a jungle/forest setting. While laying on the bench, looking up at the trees and vegetation, the experience began to exponentially increase in strength.

Within 30 minutes I messaged a friend, who was helping assess my mental acuity and document trip notes, notifying him that the experience was intensifying. My visual field continued to rapidly increase. Even while peaking on the initial dosage (+2:15ish if I had to estimate) I was able to differentiate objects/nature however that began to be no longer the case. Trees began to morph into larger entities and "sacred geometry" dominated my perception of everything surrounding me.

An incredible component of this was the level of control I had; I was fully able to type detailed, grammatically correct, and clear texts of the experience to my associate (in the moment) but when I looked away from my phone my field of vision began to become unrecognizable from reality.

We discussed the state of my ego, which was largely still in-tact. At this point my visual experience began to rival 7-8g+ Psilocybin experiences, but without any of the confusion and ego dissolution typically associated with that level of intake. He went so far as to comment that unless otherwise told, my mental "presentness" was close to indistinguishable from baseline.

As the experience continued to ramp up I decided to move off the main trail where people were passing closely by to a more secluded area. This is where I peaked, and I can only attribute the experience that followed to the potentiation/addition of the Noopept.

My visual experience was on par with complete ego-dissolution, 1,000ug+ LSD experiences but the clarity of ego & my mental state was astounding. Reality shattering worlds evolved before me, on par with strong DMT experiences.

It became impossible to separate what was actually in front of me from what my brain had created in its place. Despite this though, I could still speak, function, and text without significant impairment, and had an undeniable grasp on who I was, where I was, and what was occurring.

The visual nature was completely unique, I am certain that Noopept not only potentiated, but also dramatically changed the visual experience. It provided an almost Phenethylamine-esque neon vibrancy that I've yet to experience with Tryptamines, but this change in character did not detract from the core aspects of Tryptamine visuals.

I was unaware that one could experience that level of sensory and visual detachment without, at least, the partial loss of awareness and one's ego. It was truly a breathtaking experience, and one cemented in memory unlike previous DMT and massive dose 4-AcO-DMT/Psilocybin/LSD trips which are hazy in recollection.

+8:00 - After returning from the park, at around the 8 hour mark, I took 1mg of Alprazolam to calm the experience. Despite this, visual alterations did not conclude until ~11hrs after initial dosing.

Conclusion

Noopept undeniably increases and alters both the visual and mental aspects of the "Tryptamine Experience" in a potent yet beautiful way. While others' experiences may vary, I found the addition of Noopept to:

Reduce Anxiety
Increase Energy and Physical/Motor Functionality
Decrease Ego Dissolution
Massively Increase and Modify the Visual Experience
Extends Trip Length

Next Steps / Notes

For my next experiment I plan to give some time between dosing and then approach less cautiously to confirm the experience above was not driven by the additional smaller dosage of 4-HO-MET and not Noopept. I'll be taking the same dose as my previous experience without any additives (30mg 4-HO-MET) along with 20mg of Noopept so I have a more precise comparison basis. If the results don't differ substantially than that previous trip, I'll be able to conclude I was incorrect in my analysis and the state I reached was not due to Noopept. Given my extensive experience with 4-Sub Tryptamines however, I'm confident the two will differ substantially.

I would strongly advise caution in this combination for others. The two have a truly powerful and profound synergy and I do not suffer from anxiety or underlying conditions that have ever resulted in a bad trip across my ~50 or so experiences in the last 5 years. For others the combination could definitely prove to be less manageable and I've come across bad experience reports in connection with Noopept and Psychedelics. 4-HO-MET in particular, for myself, is very light in headspace impairment and I could see possible confusion and negative effects if combined with heavier substances like 4-ACO-DMT and ETH-LAD.

Exercise caution and harm prevention, start slow and always be cautious!

Exp Year: 2022	ExpID: 118682
Gender: Male
Age at time of experience: 26
Published: Jul 13, 2025	Views: Not Supported
[ View PDF (to print) ] [ View LaTeX (for geeks) ] [ Swap Dark/Light ]
Noopept  (579), 4-HO-MET (436) : Public Space (Museum, Park, etc) (53), Combinations (3)