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A problematic account was posted online reporting after ingesting 2.25 grams of ground syrian rue seeds along with 3 grams of dried Psilocybe cubensis while fasting.

The problems started at about the seventh hour after ingestion, well into the "comedown" and continued for about 90 minutes.

Symptoms: Cold sweats, shallow labored breathing, dementia, loss of ability to articulate, involuntary spasms (full body, legs, arms, and stomach), dangerously low blood pressure and weakened pulse - all of which literally stopped all at once after lasting about 90 minutes. Nausea and serious fatigue followed and lasted for another full 12 hours. Additional physical fatigue lingered for almost 24hrs.

Compare to the symptoms of serotonin syndrome and of a hypertensive crisis.

Similarly bad sounding accounts (severe headache, stiff neck, disorientation, malaise, muscular weakness, nausea and confusion) have been occasionally reported from people eating yogurt or fermented soy products during their experience with ayahuasca analogs or mushroom.