Several varieties of Morning Glory seeds contain LSA. LSA is a chemical closely related to LSD with similar but different effects. Following are approximate dosages for Morning Glory seeds in number of seeds. Effect intensity and duration are generally dose-dependent and the concentration of psychoactive alkaloids in morning glory seeds vary widely (as in most plants).

Dosages for Morning Glory seeds vary over a wide range. Of the 39 morning glory experience reports as of December 2000, the 5 rated with 'strong' intensity describe taking between from 280-525 (rough approximation) seeds, the 'medium' intensity reports vary between 125 and 600 seeds, and the light experiences vary between 25 and 700.

There are a number of confounding factors in trying to interpret the available data including the many different seed sources, the reported variation in potency from the same seed supplier from order to order, and widely varying preparation / extraction techniques. One interesting piece of data is that 4 of the 5 'strong' experiences used no solvent wash as part of the preparation, but many of the other reports do include washing with naptha or other non-polar solvent. This link is tenuous, at best, but may be worth further investigation.

One very experienced Morning Glory seed user has written a report which suggests that 150-250 seeds would be a minimal dose and with "a strong batch of seeds" 500-1000 seeds would produce a "psychedelic" experience. In private correspondence, this author also described taking 1-2 thousand seeds from weaker batches.

"Experienced users of entheogenic morning glory seeds usually start with low doses, later working up to higher amounts if a more intense effect is desired. The wise user will begin with no more than 4 or 5 seeds of Argyreia nervosa, or no more than 20-25 seeds of Ipomoea violacea. Seeds of Turbina corumbosa are about one fifth as potent as the seeds of Ipomoea violacea. In Mexico, I have seen doses of the true ololiuhqui seeds, Turbina corymbosa, measured as the quantity of seeds which will fill a bottle cap, and Wasson also reported this volumetric dosage aid in the Sierra Mazateca (Wasson 1963). Osmond found 60-100 seeds Turbina corymbosa seeds to be an active dose, though he chewed and ingested the whole seeds, rather than making a cold water infusion of ground seeds (Osmond 1955; see Note 11).

The seeds are not ingested whole--they are not active in this form (Kinross-Wright 1959; B.P. Reko 1934). They are ground to a fine powder, which is then steeped for several hours in cold water, after which the solid matter is filtered off and discarded. The liquid is then drunk neat or with juice for flavoring." (Ott Pharmacotheon 1993, pg. 140)

"[Ergine] is an active compound and has been established as a major component in morning glory seeds. It was assayed for human activity, by Albert Hofmann in self trials back in 1947, well before this was known to be a natural compound. An I.M. administration of a 500 microgram dose led to a tired, dream state with an inability to maintain clear thoughts. After a short period of sleep, the effects were gone and normal baseline was recovered within 5 hours." (Shulgin, TIHKAL, 1997, page 497)

"The slight difference in chemical structure between the ololiuqui constituents and LSD is very significant with regard to hallucinogenic acitivity. The effective oral dose in man of LSD is 0.05 mg [which] is thus about 50 to 100 times more active than lysergic acid amide, which is active in doses of 2 to 5 mg. Furthermore there is not only a quantitative difference between the principles of Ipomoea violacea and Turbina corymbosa and LSD; there is likewise a qualitative one, LSD being a very specific hallucinogen, whereas the psychic effects of lysergic acid amide and the total alkaloids of these two plants are characterized by a pronounced narcotic component (Hofmann, 1968)" ( Botany & Chemistry of Hallucinogens, Shultes & Hofmann, 1980)