Nicotine Material Safety Data Sheet(s)
Other Material Safety Information for Nicotine:
l-Nicotine, 99+% 96314 **** SECTION 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION **** MSDS Name: l-Nicotine, 99+% Catalog Numbers: AC181420000, AC181420050, AC181420250, AC181421000 Synonyms: S-(-)-Nicotine, B-Pyridyl-a-N-Methylpyrrolidine. Company Identification: Acros Organics N.V. One Reagent Lane Fairlawn, NJ 07410 For information in North America, call: 800-ACROS-01 For emergencies in the US, call CHEMTREC: 800-424-9300 **** SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS **** +----------------+--------------------------------------+----------+-----------+ | CAS# | Chemical Name | % | EINECS# | |----------------|--------------------------------------|----------|-----------| | 54-11-5 |Nicotine | 99 | 200-193-3 | +----------------+--------------------------------------+----------+-----------+ Hazard Symbols: T+ Risk Phrases: 25 27 **** SECTION 3 - HAZARDS IDENTIFICATION **** EMERGENCY OVERVIEW Appearance: colorless to light yellow. Danger! May be fatal if swallowed. May be fatal if absorbed through the skin. Hygroscopic. This substance has caused adverse reproductive and fetal effects in animals. May cause central nervous system depression. Poison! May cause cardiac disturbances. May cause digestive tract irritation with nausea, vomiting, and diarrhea. Target Organs: Central nervous system, respiratory system, muscles. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be fatal if absorbed through the skin. Ingestion: May be fatal if swallowed. May cause adverse effects of the musculature. May cause severe digestive tract irritation with abdominal pain, nausea, vomiting and diarrhea. May cause tremors and convulsions. May cause muscle paralysis, respiratory failure, and possible death. Exposure causes initial nervous system stimulation followed by severe CNS depression. May cause ataxia and incoordination. Inhalation: May cause effects similar to those described for ingestion. Chronic: May cause digestive tract and cardiac disturbances. **** SECTION 4 - FIRST AID MEASURES **** Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower lids. Get medical aid. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Discard contaminated clothing in a manner which limits further exposure. Destroy contaminated shoes. Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Notes to Physician: Treat symptomatically and supportively. **** SECTION 5 - FIRE FIGHTING MEASURES **** General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Can form explosive mixtures at temperatures above the flashpoint. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Extinguishing Media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam. Water or foam may cause frothing. Autoignition Temperature: 240 deg C ( 464.00 deg F) Flash Point: 101 deg C ( 213.80 deg F) NFPA Rating: health-4; flammability-1; reactivity-0 Explosion Limits, Lower: .70 vol % Upper: 4.00 vol % **** SECTION 6 - ACCIDENTAL RELEASE MEASURES **** General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Avoid runoff into storm sewers and ditches which lead to waterways. Wear a self contained breathing apparatus and appropriate Personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Absorb spill using an absorbent, non-combustible material such as earth, sand, or vermiculite. **** SECTION 7 - HANDLING and STORAGE **** Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Do not reuse this container. Do not get on skin or in eyes. Do not ingest or inhale. Storage: Keep away from sources of ignition. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Keep away from strong acids. **** SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION **** Engineering Controls: Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits +--------------------+-------------------+-------------------+-----------------+ | Chemical Name | ACGIH | NIOSH |OSHA - Final PELs| |--------------------|-------------------|-------------------|-----------------| | Nicotine |0.5 mg/m3; skin - |0.5 mg/m3 TWA 5 |0.5 mg/m3 TWA | | |potential for | mg/m3 IDLH | | | |cutaneous | | | | |absorption | | | +--------------------+-------------------+-------------------+-----------------+ OSHA Vacated PELs: Nicotine: 0.5 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear impervious gloves. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. **** SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES **** Physical State: Liquid Appearance: colorless to light yellow Odor: Slight fish odor when warm. pH: 10.2 Vapor Pressure: 1 mm Hg @ 61.8C Vapor Density: 5.61 (air=1) Evaporation Rate: Not available. Viscosity: exposure to air Boiling Point: 247 deg C @ 760.00mm Hg Freezing/Melting Point: -80 deg C Decomposition Temperature: Not available. Solubility: IN WATER: MISCIBLE BELOW 60ŚC Specific Gravity/Density: 1.0100g/cm3 Molecular Formula: C10H14N2 Molecular Weight: 162.23 **** SECTION 10 - STABILITY AND REACTIVITY **** Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong acids, strong oxidizers. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen. Hazardous Polymerization: Has not been reported. **** SECTION 11 - TOXICOLOGICAL INFORMATION **** RTECS#: CAS# 54-11-5: QS5250000 LD50/LC50: CAS# 54-11-5: Oral, mouse: LD50 = 3340 ug/kg; Oral, rat: LD50 = 50 mg/kg; Skin, rabbit: LD50 = 50 mg/kg; Skin, rat: LD50 = 140 mg/kg. Carcinogenicity: Nicotine - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Epidemiology: No information available. Teratogenicity: Effects on Newborn: Biochemical and metabolic, orl-rat TDLo=59400 ug/kg; Stillbirth, scu-rat TDLo=9 mg/kg. Embryo or Fetus: Death, ipr-mouse TDLo=24 mg/kg; Stunted fetus, ipr-rat TDLo=5250 ug/kg. Specific Developmental Abnormalities: Craniofacial, ipr-mouse TDLo=1 mg/kg; Musculoskeletal, orl-mouse TDLo=16 mg/kg. Reproductive Effects: Fertility: Litter size, scu-mouse TDLo=25 mg/kg. Maternal Effects: Postpartum effects, scu-rat TDLo=22500 ug/kg. Neurotoxicity: No information available. Mutagenicity: DNA Inhibition: rbt-cell types 1mmol/L. Other Studies: Please refer to RTECS QS5250000 for additional data. **** SECTION 12 - ECOLOGICAL INFORMATION **** Ecotoxicity: Fish (fresh water) 3-29ppm toxic (time period not specified). Environmental Fate: No information reported. Physical/Chemical: No information available. Other: None. **** SECTION 13 - DISPOSAL CONSIDERATIONS **** Dispose of in a manner consistent with federal, state, and local regulations. RCRA D-Series Maximum Concentration of Contaminants: None listed. RCRA D-Series Chronic Toxicity Reference Levels: None listed. RCRA F-Series: None listed. RCRA P-Series: CAS# 54-11-5: waste number P075. RCRA U-Series: None listed. CAS# 54-11-5 is banned from land disposal according to RCRA. **** SECTION 14 - TRANSPORT INFORMATION **** US DOT Shipping Name: NICOTINE Hazard Class: 6.1 UN Number: 1654 Packing Group: II IMO No information available. IATA No information available. RID/ADR No information available. Canadian TDG Shipping Name: NICOTINE Hazard Class: 6.1 UN Number: UN1654 **** SECTION 15 - REGULATORY INFORMATION **** US FEDERAL TSCA CAS# 54-11-5 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules None of the chemicals in this product are under a Chemical Test Rule. Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. SARA Section 302 (RQ) CAS# 54-11-5: final RQ = 100 pounds (45.4 kg) Section 302 (TPQ) CAS# 54-11-5: TPQ = 100 pounds; RQ = 100 pounds (calculated TPQ change d after technical review as described in the technical support docume nt) SARA Codes CAS # 54-11-5: acute, chronic. Section 313 This material contains Nicotine (CAS# 54-11-5, 99%),which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373. Clean Air Act: This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors. Clean Water Act: None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA. OSHA: None of the chemicals in this product are considered highly hazardous by OSHA. STATE Nicotine can be found on the following state right to know lists: California, New Jersey, Florida, Pennsylvania, Minnesota, Massachusetts. WARNING: This product contains Nicotine, a chemical known to the state of California to cause birth defects or other reproductive harm. California No Significant Risk Level: None of the chemicals in this product are listed. European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: T+ Risk Phrases: R 25 Toxic if swallowed. R 27 Very toxic in contact with skin. Safety Phrases: S 36/37 Wear suitable protective clothing and gloves. S 45 In case of accident of if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 54-11-5: No information available. Canada CAS# 54-11-5 is listed on Canada's DSL/NDSL List. This product has a WHMIS classification of D1A, D2B. CAS# 54-11-5 is not listed on Canada's Ingredient Disclosure List. Exposure Limits CAS# 54-11-5: OEL-ARAB Republic of Egypt:TWA 0.5 mg/m3;Skin OEL-AUSTRALIA:TWA 0.5 mg/m3;Skin OEL-BELGIUM:TWA 0.5 mg/m3;Skin OEL-DENMARK:TWA 0.5 mg/m3;Skin OEL-FINLAND:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin OEL-FRANCE:TWA 0.5 mg/m3;Skin OEL-GERMANY:TWA 0.07 ppm (0.5 mg/m3);Skin OEL-HUNGARY:STEL 0.5 mg/m3;Skin OEL-THE NETHERLANDS:TWA 0.07 ppm (0.5 mg/m3);Skin OEL-THE PHILIPPINES:TWA 0.5 mg/m3;Skin OEL-POLAND:TWA 0.5 mg/m3 OEL-SWITZERLAND:TWA 0.07 ppm (0.5 mg/m3);STEL 0.1 ppm;Skin OEL-THAILAND:TWA 0.5 mg/m3 OEL-TURKEY:TWA 0.5 mg/m3;Skin OEL-UNITED KINGDOM:TWA 0.5 mg/m3;STEL 1.5 mg/m3;Skin OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV **** SECTION 16 - ADDITIONAL INFORMATION **** MSDS Creation Date: 2/01/1996 Revision #1 Date: 12/16/1997 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages. --------------------------------------------------------------------------------