Erowid References Database
|
Teitler M, Leonhardt S, Appel NM, De Souza EB, Glennon RA.
“Receptor pharmacology of MDMA and related hallucinogens”.
Ann N Y Acad Sci. 1990;600:626-38; discussion 6.
|
|
Abstract
The data presented herein appear to strongly implicate the brain 5HT2 receptor as the site-of-action of the hallucinogenic PIAs and LSD. If so, this discovery represents a major step in understanding the molecular pharmacology of hallucinogenic drugs. Using radioactive hallucinogenic drugs, detailed properties of brain 5HT2 receptors indicating the interaction of 5HT2 receptors with GTP-binding proteins have been revealed. Autoradiographic studies have revealed an extensive cortical distribution of brain 5HT2 receptors; these studies have also suggested that the PIAs may be 5HT1C agonists. Radiolabeling studies in conjunction with drug discrimination studies indicate that MDMA is apparently 'amphetamine-like' and not 'LSD-like' while MDA is apparently both 'LSD-like' and 'amphetamine-like.' However, MDMA does appear to possess the potential to act as a 5HT2 agonist at high dosages.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
