Erowid References Database
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Morgan AE, Horan B, Dewey SL, Ashby CR Jr.
“Repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens: a microdialysis study”.
Eur J Pharmacol. 1997 Jul 16;331(1):R1-R3.
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Abstract
In this study, we examined the ability of a single injection of cocaine (20 mg/kg, i.p.) to augment extracellular dopamine levels in the nucleus accumbens two weeks after pretreating rats with either saline (1 ml/kg, i.p.) or the serotonin neurotoxin 3,4-methylenedioxymethamphetamine (20 mg/kg, s.c., twice daily for 4 days). The level of dopamine in the nucleus accumbens was measured using in vivo microdialysis. Cocaine produced a 400% increase in extracellular nucleus accumbens dopamine levels in control rats, whereas in 3,4-methylenedioxymethamphetamine treated rats the increase produced by cocaine was 800%, which was significantly different from controls. This suggests that 3,4-methylenedioxymethamphetamine, a relatively common drug of abuse, may alter subsequent vulnerability to cocaine dependence and abuse.
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