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Aghajanian GK, Liebermann JA.
“Caveat Emptor: Editors Beware”.
Neuropsychopharmacology. 2001;24(3):335-6.
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Abstract
In their letter (see pg. 333), McCann and Ricaurte (2001) raise objections to a Neuropsychopharmacology edito-rial (Lieberman and Aghajanian, 1999) pertaining to the article by Vollenweider et al. (1998) and a subsequent letter-to-the-editor by Gijsman et al. (1999). Our editorial stated, '... the data do not support the view that single oral doses at 1.7 mg/kg of MDMA are likely to produce damage to serotonin terminals in human' (Lieberman and Aghajanian, 1999). McCann and Ricaurte argue that if interspecies dose scaling is applied to the human dose that was used by Vollenweider et al. (1999) (i.e., 1.7 mg/kg), this would be within the range of the 'known' single oral neurotoxic dose of MDMA in the monkey (5.0 mg/kg). It should be noted, how-ever, that our editorial was aimed at the issue, of whether it had actually been demonstrated that a single 5.0 mg dose of MDMA was in fact neurotoxic in the monkey.
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