Erowid References Database
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Hoagland H, Rinkel M, Hyde RW.
“Adrenocortical function and urinary phosphate excretion. Comparison in schizophrenia and in lysergic acid diethylamide-induced psychotic episodes in normal persons.”.
Arch. Neurol. & Psychiat.. 1955;73:100.
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Abstract
In normal subjects, LSD (0.5-1.0 mcg/kg by mouth) reduced the excretion of inorganic urinary phosphates. While the subjects were under the influence of LSD, 25 mg. corticotropin markedly enhanced the excretion of inorganic phosphate. Thus, the behavior of phosphates at rest and under the impact of adrenocorticoids in the LSD-treated normal subjects is similar to that found in schizophrenic patients not given LSD. Similar results were obtained in guinea pigs. The findings indicate that LSD appears to stimulate the pituitary-adrenal axis and leaves the adrenals somewhat unresponsive to corticotropin [cf. Rinkel et al, S0-0067]. It is suggested that LSD acts on enzyme systems to facilitate the binding of phosphate. Adreno-corticoids may release the phosphate from its bound form and thus account for the marked output of urinary phosphate in schizophrenic patients and in normal subjects under the influence of LSD following the action of corticoids. An endogenous derivative of adrenaline metabolism may act in schizophrenic patients in a similar manner to that in which LSD acts in normal subjects.
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