Erowid.org: Erowid Reference 1546 : Experimental analysis of the inhibitory action of lysergic acid diethylamide on cortical dendritic activity. : Purpura DP

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Purpura DP. “Experimental analysis of the inhibitory action of lysergic acid diethylamide on cortical dendritic activity.”. Ann. N.Y. Acad. Sc.. 1957;66:515. <a name="ref">Purpura DP.</a> <a href="/references/1546">"Experimental analysis of the inhibitory action of lysergic acid diethylamide on cortical dendritic activity."</a> <i>Ann. N.Y. Acad. Sc.</i>. 1957;66:515.
Texts Abstract (this page) Full Text - Multiple (129 K) Full Text - English (1282 K) Show Articles by Purpura DP Article IDs LSDID: 0304 Erowid RefID: 1546 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract Studies in cats (Purpura: Arch.Neurol.Psychiat., 75: 122, 1956) have shown that LSD inhibits dendritic responses. As the dendrites are only activated synaptically, LSD must have a synaptic site of action. It is thought that LSD activates inhibitor synapses accessible to transmitter substances released by reticular stimulation of the brainstem as shown in cross-circulation studies. The net result of the action of LSD appears to be an EEG pattern resembling that of arousal. This may represent a competitive type of blockade of reticulocortical synapses.
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