Erowid.org: Erowid Reference 1638 : Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat's paw by serotonin : Doepfner W, Cerletti A

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Doepfner W, Cerletti A. “Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat's paw by serotonin”. Int. Arch. Allergy. 1958;12:89-97. <a name="ref">Doepfner W, Cerletti A.</a> <a href="/references/1638">"Comparison of lysergic acid derivatives and antihistamines as inhibitors of the edema provoked in the rat's paw by serotonin"</a> <i>Int. Arch. Allergy</i>. 1958;12:89-97.
Text Abstract (this page) Full Text - English (428 K) Show Articles by Doepfner W Cerletti A Article IDs LSDID: 0509 Erowid RefID: 1638 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract The edema induced in the rat paw by local injection of serotonin is more marked than that induced by amounts of histamine which are 200 times as great. . The serotonin-induced edema is easily blocked by various amide derivatives of lysergic acid. Two of these derivatives, the methyl derivatives of ergonovine and methyl-ergonovine, proved to be more powerful anti- serotonins than LSD. . Of the eight antihistamines studied, only representatives of the phenothiazine and piperidine groups markedly inhibited the serotonin-induced edema. The doses necessary were 100-1000 times as great as those of the most potent lysergic acid derivatives.
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