Erowid References Database
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Weidmann H, Cerletti A.
“Weiterer Beitrag zur Pharmakologie von D-Lysergsäure-diäthylamid: Die Wirkung von LSD auf Kreislaufreflexe”.
Helvet. physiol. et pharmacol. acta. 1958;16:C 38- C 39.
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Abstract
LSD inhibited the pressor effect of bilateral carotid occlusion in cats under urethane-chloralose anesthesia. The doses required for this inhibition (20 mcg/kg by i.v. injection, 30-35 mcg/kg by slow i.v. infusion) had no appreciable effect on the peripheral circulation. In its inhibitory action on proprioceptive circulatory reflexes, therefore, LSD shows only a quantitative difference from other compounds of the ergot group, viz., it is 5-10 times less active than Gynergen. . The blood pressure reaction to stimulation of the sciatic nerve shortly after the commencement of a slow i.v. infuison of LSD was enhanced in most instances. This applied to both pressor and depressor reactions. During a lengthy infusion, inhibition first of the depressor and subsequently of the pressor reaction, was frequently observed. . Thus LSD enhances this heteroceptive circulatory reflex which probably involves higher parts of the brain, in the same doses which inhibit the proprioceptive carotid occlusion reflex (centre in the medulla oblongata). Small doses of LSD failed to enhance the blood pressure effect of sciatic nerve stimulation in decerebrated cats.
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