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Monnier M, Tissot R.
“L'action de la réserpine-sérotonine sur le cerveau; suppression par les antagonistes de la réserpine: iproniazid (Marsilid) et LSD”.
Schweiz. Arch. Neurol.. 1958;82:218-228.
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Abstract
The changes in the EEG accompanying the sedative effect of reserpine alone (0.5 - 1.5 mg/kg i.v.) in rabbits are described. . Iproniazid (80 mg/kg s.c. or i.m.), given 14-20 hours before reserpine (0.5 - 1.5 mg/kg i.v.) prevents the sedative effects of reserpine. . LSD (25-35 mcg/kg i.v.) induced a state of alertness with considerable neuromuscular excitement. These symptoms were accompanied by total desynchronization in the neocortex and synchronization in the palaeo- cortex (hippocampus) and the cortical diencephalic structures. The desynchronization was frequently generalized. The respone of the intralaminary medial thalamic system to stimuli was reduced, that of the mesencephalic reticular system was increased. Initially, the hippocampus exhitibed marked excitement, eliciting spontaneous discharges and occasional motor attacks. . Reserpine (0.7 mg/kg) given after LSD (25 mcg/kg i.v.) exerted no sedative effect during the first hour. This appeared later. The inhibition by LSD of this effect of reserpine is probably not due to biochemical antagonism such as exists between oproniazid and reserpine. The sedative effect of reserpine seems to be compensated by the stimulating, ergotropic effect of LSD, as is the case with amphetamine.
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