Erowid References Database
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Jarvik ME, Chorover S.
“Impairment by lysergic acid diethylamide of accurracy in performance of a delayed alternation test in monkeys.”.
Psychopharmacologia. 1960;1:221.
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Abstract
Eight monkeys were trained to press alternately one of two panels to be rewarded by small amounts of water. A light signal gave the time for the successful response (in right choice of appropriate panel) every 2 seconds. . Doses as low as 0.005 mg/kg i.m. (15 minutes before the test) affected the exact performance on the panels, of which the frequency was reduced only by higher dosage. After 0.025 mg/kg (4 animals) at least a 30 0.000000all of accuracy occurred, after 0.005 mg/kg (4 animals) it was less than 21%. After 0.025 mg/kg only 1 monkey pressed the panels more than 100 times during the 1/2 hour experiment, after 0.005 mg/kg all 4 animals pressed them at least 100 times. . Injection of LSD on consecutive days showed the development of tolerance to the particular dose even after free periods of 1-2 weeks. . Amphetamine and chlorpromazine (0.5 mg/kg) depressed responding rate without affecting accuracy. Pentobarbital generally depressed rate less than chlorpromazine except in 1 animal where it actually increased the number of responses. One monkey was anesthetized by larger doses of pentobarbital (20.0 mg/kg). . The results obtained following LSD administration resemble those seen in monkeys with frontal lobe lesions, which might be due to common factors.
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