Erowid References Database
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Malis JL, Brodie DA, Moreno OM.
“Drug effects on the behavior of self-stimulation monkeys”.
Federation Proc.. 1960;19:23.
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Abstract
Rhesus monkeys were allowed to press a lever to obtain intracranial stimulations (trains of rectangular pulses through electrodes into the medial forebrain) on a continuous reinforcement schedule (one lever press yields one brain stimulation) or on a ratio schedule (10-150 lever presses yield one brain stimulation). Several drugs were injected i.p. . Pentobarbital, chlorpromazine and scopolamine reduced or abolished lever pressing; caffeine and d- amphetamine increased the rate of lever pressing. LSD (0.05-0.25 mg/kg) caused erratic lever pressing with periods of high activity rates. . "Bipolar stainless steel electrodes were implanted in the vicinity of the medial forebrain bundle of adult Rhesus monkeys. Trains of rectangular pulses (0.2 msec. pulse width, 0.2 sec. train length, 200 pulses/sec.) were delivered through a suitable isolation transformer. The monkeys were allowed to press a lever to obtain intracranial stimulation, either on a continuous reinforcement schedule (one lever press yeilds one brain stimulation) or on a ratio schedule (10-150 lever presses yield one brain stimulation). Dose-response curves were obtained for the drugs on both types of performance. All drugs were injected intraperitoneally. Pentobarbital (7.5-30.0 mg/kg), chlorpromazine (1.0-5.0 mg/kg) and scopolamine (0.01-0.1 mg/kg) reduced or abolished lever pressing while caffeine (25-200 mg/kg) and d-amphetamine (0.25-2.0 mmg/kg) increased the rate of lever pressing. Lysergic acid diethylamide (.050-.250 mg/kg) produced erratic lever pressing behavior which was characterized by varying periods of high rates of activity. Ratio performance was more sensitive to the effects of stimulant drugs than the continuous reinforcement schedule."
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