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Fink M.
“EEG and behavioral effects of psychopharmacologic agents.”.
Neuro-Psychopharmacology. 1959;p441.
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Abstract
EEGs were taken from psychiatric patients [number not mentioned] prior to, during and after administration of several psychopharmaceuticals. The medications (affecting behavior) were given orally for extended trials (e.g. reserpine, meprobamate) or i.v. in acute experimental trials (e.g. LSD, diethazine). . Four broad types of EEG patterns may be identified. 1. Increase in slow wave activity and in synchrony (e.g. oral chlorpromazine). 2. Increase in synchrony without frequency shift (e.g. oral chlorpromazine). 3. Increase in fast wave activity and in synchrony (e.g. amobarbital i.v.) 4. Desynchronization and frequency irregularity (e.g. oral LSD or the anticholinergic WIN-2299 i.v.) . In subjects with post-convulsive delta activity LSD decreased voltage and per cent time of slow wave activity. . Behavioral changes were invariably associated with EEG changes: sedation and euphoria with synchronization, excitement and hallucinations with desynchronization. Sedation and euphoria were observed following chlorpromazine, promazine, triflupromazine and amobarbital, excitement following amphetamine, excitement tension and panic also following benactyzine. After LSD, hallucinations, delusional, paranoid ideation occurred in addition to excitement, tension, and panic. . The observations agree with the hypothesis that clinical efficacy of psychotropic drugs depends upon induced alteration in cerebral function as a milieu for changes in the interaction with the environment.
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| Notes # : Proceedings of the 1st International Congress of Neuro-Psychopharmacology, Rome, September 1958 |
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