Erowid References Database
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Fink M, Jaffe J, Kahn RL.
“Drug-induced changes in interview patterns: linguistic and neurophysiologic indices”.
The Dynamics of Psychiatric Drug Therapy. 1960;p29.
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Abstract
EEG's and recordings of language patterns were taken before and after administration of various drugs: amobarbital, benactyzine, chlorpromazine, diethazine, iproniazid, LSD (75-100 mcg. i.v.) and WIN-2299 (2- diethyl-aminoethyl-cyclopentyl-2-thienyl-glycolate). . EEG: Drugs that increase EEG synchronization or induce a shift in EEG frequencies to the slow range as amobarbital or chlorpromazine induce behavioral changes of sedation. Drugs that desynchronize the record, however, or induce irregular fast activity as diethazine, benactyzine , LSD and WIN-2299, are associated with hallucinatory, excitatory or illusory activity. . Language analysis: With chlorpromazine and amobarbital there is a decrease in the mean type-token-ratio (TTR) and an increase in variability of consecutive scores. TTR is a psychological index of language diversity; the ratio reflects the number of different words (types) to the total number of words (the tokens) in the sample. Diethazine, benactyzine, LSD and WIN-2299 increase the mean TTR and decrease the variability. . The authors believe that language changes are an important factor on which the evaluation of improvement are based. .
PURPOSE: The classification of drugs attempt to describe complex physiologic and psychologic processes by global, subjective, nonoperational terms. The EEG measures neurophysiologic changes and the language measures changes in interpersonal communication.
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