Erowid References Database
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Krivoy WA.
“Potentiation of substance P by lysergic acid diethylamide in vivo”.
Brit.J.Pharmaco.. 1961;16:253-256.
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Abstract
Substance P has been considered to be the synaptic transmitter from first to internuncial and secondary sensory neurones in the spinal cord. LSD inhibits an enzyme-destroying substance P (Krivoy, Brit.J.Pharmacol. 12: 361 (1957)). To evaluate the action of substance P on transmission, the effects of i.v. LSD, subtance P and BOL 148 on dorsal root (DR) potentials evoked by maximal and submaximal stimuli (0.5 and 2.5 cycles/sec.) were studied in 23 decerebrated cats including 4 with additional spinal transection. . Submaximal stimulation at 2.5 cycles/sec.: LSD enhanced DR potentials in the IV deflection. 5 mcg/kg LSD produced enhancement in about half the cats, 10 mcg/kg LSD in every cat. Substance P alone had no effet, but it enhanced DR potentials after small doses of LSD (5 mcg/kg) which per se are not always effective. - BOL 148 up to 100 mcg/kg had no action on DR potentials, but blocked the effect of subsequent LSD. . There were no differences between decerebrate and decerebrate-spinal cats. . Maximal stimulation at 2.5 cycles/sec: very large doses of LSD were required for enhancement. . Maximal and submaximal stimulation at 0.5 cycles/sec.: No clear-cut action on DR potentials by LSD and substance P.
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