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Krendal F P. Kudrin N.
“Comparative Investigation of the Antipsychotic Action of some Neuroleptics on the Model of LSD-Psychosis”.
Zh.Nevropatol.Psikhiatr.. 1973;73(5):747-53.
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Abstract
The comparative effect of aminazine, haloperidol and droper-idol on LSD-psychosis in rabbits is reported. Methods Experiments were conducted on 28 rabbits in light urethane narcosis. LSD-25 was administered (a) 5-60mcg/kg i.v. (b) by cannula into the side ventricles of the brain (0.1: 5 Mg/kg in 0.001-0.15 ml of solution) or (c) by cannula into the retriculár formations and hippocampus (0.1 - .3 mcg/kg In 0.001 - 0.1 ml of solution) Czech LSD preparation lysergamide (SPOFA) was used. Aminazinc, haloperidol and droperidol were administered i.v. in doses of 0.5 -1 0 mg/kg, and also directly into the reticular formations. Aminazine i.v. at 3-5 mg/kg, intraventricularly at 0.8 - 1.2 mg/kg, or 0.3 - 0.5 mg/kg in the reticular formations of the brain removed the behavioural, vegetative and EEG manifestations of LSD psychosis. Extrapyramidal disturbances occurred when aminazine (3-5 mg/kg) was administered to animals in conditions of fear, tension and motor stimulation. Haloperidol i.v. at 2 - 2.5 mg/kg and droperidol at 1-1.5 mg/kg immediately after LSD abolished the EEG changes caused by LSD. After droperidol, there was a tendency for normal electrical activity of the brain to occur. With i.v. droperidol, the effects of LSD were liquidated within 15-20 min. Similar results were obtained when droperidol was introduced into the reticular formations at 0.12 - 0.25 mg/kg. When haloperidol was given at the height of LSD psychosis, extra-pyramidal disturbances occurred. The use of haloperidol as an antagonist of LSD requires the use of specific correctors such as phenitron or P-28. Of the 3 substances studied, droperidol was the most successful LSD antagonist.
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