Erowid References Database
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Peters DAV.
“Comparison Of The Chronic And Acute Effects Of D-lysergic Acid Diethylamide (LSD) Treatment On Rat Brain Serotonin And Norepinephrine”.
Biochem Pharmacol. 1974;23:231-237.
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Abstract
The effects of repeated administration of small doses of D-lysergic acid diethylamide (LSD) on brainstem norepinephrine (NE), serotonin (5-HT), 5-hydroxy - indoleacetic acid (5-HIAA), tyrosine, tryptophan, tyrosine hydroxylase and tryptophan hydroxylase have been studied in male Sprague-Dawley rats. A daily dose of 20 mcg/kg given for 14 days resulted in a significantly lowered NE level and tyrosine hydroxylase activity measured 24 hr after the last injection. Treatment with 100 mcg/kg/day for the same period of time produced similar changes together with a significantly lower brain - stem tyrosine content. Evidence was obtained that the NE turnover in rat brainstem was significantly increased at the higher dose level only. The lower dose of 20 ,mcg/kg/day also resulted in an elevated 5-HT and lowered 5-HIAA content. However, when the dose was increased to 100 mcg/kg/day the 5-HT content was unchanged and the 5-,HIAA con - tent increased. The 5-HT turnover was reduced when the rats were treated with 20mcg/ kg/day but significantly elevated when the 100-mcg dose was used.
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