Erowid References Database
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Appel JB, Sheard, MH, Freedman DX.
“Alterations in the behavioral effects of LSD by midbrain raphe lesions.”.
Behavioral. Biology.. 1970;5(4):237-241.
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Abstract
To investigate the relationship between brain serotonin and LSD and to control for the peripheral and other central effects of drug pretreatment, sensitivity to LSD was studied in rats with electrolytic lesions in the midbrain raphe nuclei. Rats were trained to press a bar on a fixed ratio schedule of food reinforcement. The lesions, which caused a significant depletion of serotonin and its chief metabolite 5-hydroxyindoleacetic acid in the forebrain, markedly enhanced the disruptive effects of a subthreshold of LSD on this behavior. 15 references. (Journal abstract modified)
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