Erowid References Database
|
Berridge MJ, Prince WT.
“The Nature Of The Binding Between LSD And A 5-HT Receptor: A Possible Explanation For Hallucinogenic Activity”.
Br J. Pharmac.. 1974;51:269-278.
|
|
Abstract
1. (+)-Lysergic acid diethylamide (LSD) mimicked 5-hydroxytryptamine (5-HT) in its ability to stimulate fluid secretion, to change transepithelial and intracellular potentials as well as to increase the cyclic 3 ,5 -adenosine monophosphate (cyclic AMP) concentrations of isolated salivary glands of Calliphora. 2 Unlike 5-HT, LSD disengages slowly from the receptor and fluid secretion continues despite repeated washing. 3 Both 5-HT and tryptamine prevented LSD from acting on the glands. 4 LSD bound to the receptor was slowly displaced when glands were treated with agonists (tryptamine) or antagonists (gramine). 5 The property of LSD which permits it to function as an agonist despite remaining tightly bound to the receptor is discussed as a possible basis for its profound effects within the central nervous system.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
