Erowid References Database
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King AR, Martin IL, Melville KA.
“Reversal Learning Enhanced By Lysergic Acid Diethylamide (LSD): Concomitant Rise In Brain 5-hydroxytryptamine Levels”.
Brit.Pharmacol. 1974;52:419-425.
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Abstract
Small doses of lysergic acid diethylamide (LSD) (12.5-50mcg/kg).consistently facilitated learning of a brightness discrimination reversal. 2-Bromo-lysergic acid diethylamide (BOL-148), a structural analogue of LSD, with similar peripheral anti-5-hydroxytrypamine activity but no psychotomimetic properties, had no effect in this learning situation at a similar dose (25 mcg/kg). LSD, but not BOL-148, caused a small but significant increase in brain 5-HT levels, but had no effect on the levels of catecholamines in the brain at 25 mcg/kg.
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| Notes # : Medical Research Council, Neuropharmacology Unit, The Medical School Birmingham |
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