1955). The unrewarding outcome of this study led to a loss of interest in the compound. Interest was rekindled a few years later when a flurry of reports containing rather encouraging findings in the treatment of alcoholics with LSD appeared (Osmond, 1957; 1 . Smart and Storm, 1964). In these reports there began to be outlined the use of LSD in psychotherapeutic context, rather than its use as a chemotherapeutic agent, per se. It was the possibility of enhancing this approach that led to the re-initiation of our studies with LSD in 1963.