Erowid References Database
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Pieri L, Pieri M.
“Drug-induced Rotation in Rats after Unilateral Intracerebral Injection of 5,6-Dihydroxytryptamine (5,6-HT).”.
Experientia. 1974;30(6):696-97.
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Abstract
Unilateral stereotaxic injection of 5,6-dihydroxytryptamine (5,6-HT) 10 fig in the medial forebrain bundle (MFB) of rats produced within 10 days, a marked unilateral decrease of the forebrain levels of serotonin (5-HT) and dopamine (DA) due to unilateral degeneration of serotonergic and dopaminergic non-terminal axons in the MFB. In the 5,6-HT-lesioned rats, apomorphine down to 0.1 mg/kg i.p. induced rotation towards the non-lesioned side, whereas d-methamphetamine down to 0.5 mg/kg i.p. evoked ipsilateral rotation. Haloperidol 1 mg/kg i.p. blocked the action of apomorphine (1 mg/ kg i.p.) and d-methamphetamine (3 mg/kg i.p.). LSD (100 and 200 mcg/kg i,p,) elicited contralateral rotation. LSD given for 5 consecu-tive days did not result in tolerance. Mescaline, up to 20 mg/kg i.p.,was inactive. Haloperidol 1 mg/kg i.p. also blocked the - rotation induced by LSD. LSD may thus exert an apomorphine-like direct stimulation of DA receptors.
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