Erowid References Database
|
Apokhina IP, Bondarenko TT, Zabrodin GD.
“Some General Principles of the Mechanism of Central Action of Psychotomimetics”.
Zh Nevropath Psikhiat. 1975;75(2):264-274.
|
|
Abstract
The mechanism of action of LSD, phenamine and hashish extract, and of parabrometamphetamine which is similar in structure to phenamine but lacks psychotomimetic properties, was studied. Chronic neurophysiological'ests were conducted on rabbits with implanted electrodes in various parts of the CNS, and on rats in urethane narcosis (1-1.4 g/kg i.p.). 2-5 Min after an i.v. dose of 0.02-0.03 mg/kg LSD in rabbits, stimulation occurred. With hashish extract i.v., low doses (I ma/ kg) of tetrahydrocannabinol had a sedative effect, while doses of 2.8-3.0 mg/kg led to stimulation. All preparations had an activating effect on biocurrents of the brain cortex and subcortica1 formations. On the EEG, frequent desynchronized, low-amplitude variations occurred, being most marked with DSD, and effect which became more marked with preliminary or subsequent injection of adrenaline (0.15-0.3 mg/kg) and serotonin (0.3 - 0.7 mg/kg). If parabrometamphetamine was administered in doses of 7-10 mg/kg, some stimulation occurred, and this effect was strengthened by serotonin, but inhibited by aminazine (1.5-3 mg/kg). Aminazine also had an inhibiting effect on LSD and phenamine. With prolonged (7 day) dosage of LSD and hashish in the above- mentioned doses there were generalized slow high-amplitude waves on the EEG. The reticular formations of the brain were most sensitive both to the psychotomimetics and parabrometamphetamine. Microinjections of adrenaline (0.05-0.1 mg) in the reticular formations enhanced the behavioral and bioelectric effect of LSD. A similar effect was observed with 0.5-1.0 mg serotonin. Psychotomimetics decreased noradrenaline levels in the brain and increased those of serotonin. The tendency was reversed with parabrometamphetamine.
|
| # |
| Submit Comment |
|
[
Cite HTML ]
