Erowid References Database
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Arnold OH.
“N,N-Dimethyltryptamin-: Einige erste Vergleichsergebnisse”.
Arzneimittel-Forsch.. 1975;25:972-974.
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Abstract
Some studies were performed on the influence of N,N - dimethyltryptamine (DMT) on the acoustic evoked potentials (AEP). Methods 7-Healthy male volunteers (between 20-47 yr) received s.c. DMT 1.0-1.2 mg/kg, and in a separate study I2 cats received i.v. DMT 2 mg/kg. Evoked-response audiometry (ERA) and EEG ' recordings were made in response to a sound impulse of 90 decibel (1000 Hz) as well-as to a flash of light in some cases. In - another study d-LSD was given p.o. 100mcg to human subjects and i.v. 10 mcg to cats. 10 Min after a DMT dose, the AEP was reduced, returning after 55 min in the male -subjects'. The on-off effect recorded by the EEG was also diminished. 'Subjects recognized each sound and understood every word given. LSD had no effect on AEP. Serotonin i.v. 2 mg/kg produced no change in AEP in cats, and when 23 min later DMT was given, the AEP was reduced for only '5 min. The maximal suppression of AEP in human by DMT occurred between 30-35 min. The psychopathological and vegetative activity maximum occurred on average after 15 min as signified by changes in consciousness. spatial perception, and time, acoustic and visual experiences. It was suggested that DMT may suppress the inhibitory effects of serotonin on receptors in the area postrema'and stimulate neurons of the ascending reticular system via a feed-back cycle. The reduction of AEP and the on-off effect may be due to restoration of the serotonin effect with overcompensation end - reduction in its activity. The participation of the reticular system in formation of evoked responses in the sensory field is implicated.
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