Erowid References Database
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Everitt BJ, Fuxe K, Hokfelt T.
“Serotonin, Catecholamines and Sexual Receptivity of Female Rats, Pharmacological Findings”.
J Pharmacol. 1975;6(3):269-276.
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Abstract
Changes in sexual receptivity of female rats produced by drugs which influence serotonin (5-HT) and catecholamine receptors are reported. Tests for sexual receptivity in the presence of male rats were performed on ovariectomized Sprague Dawley rats (250-300 g) treated with estradiol benzoate 2 mcg/g/day alone or combined with progesterone (500 mcg at 4-6 hr before observation) to stimulate receptivity and additionally with various drugs. Drugs were usually given i.p. in a volume of 1 ml. Of drugs acting on 5-HT neurons, sexual receptivity were increased by p - chlorophenylalanine 150 mg/kg and LSD 5-20 mcg/ kg and depressed by fenfluramine 5 mg/kg. Of drugs acting on dopamine receptors, pimozide 1 mg/kg enhanced and piribedil (ET 495) 25 mg/kg depressed sexual receptivity, while a combination of the latter with fenfluramine completely suppressed it. Of drugs acting on noradrenaline receptors, phenoxybenza-mine did not increase sexual receptivity but the addition of (+)-amphetamine 3 mg/mcg to pimozide caused an extra increase of receptivity. The dopamine-p -hydroxylase inhibitor FLA 63 25 mg/kg slightly depressed receptivity while not enhancing the depressive effect of piribedil. Of drugs acting on adrenaline receptors, piperoxan 5 mg/kg and yohimbine i mg/tkg increased sexual receptivity. The tyrosine hydroxylase inhibitor a-methyl-p-tyrosine 100 mg/kg increased sexual receptivity. Reserpine had an effect in earlier recorded experiments.
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