Erowid References Database
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McCloskey KL, Franz DN.
“Effects of LSD, Mescaline and Psilocybin on Sympathetic Preganglionic Neurons”.
Pharmacologist. 1974;16(2):237.
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Abstract
The evidence of bulbospinal control of sympathetic preganglion ic neurons (SPGN) by excitatory norepinephrine (NE) and inhibitory serotonin (5-HT) pathways prompted the use of this system as a model for studying the effects of hallucinogenic drugs on central monoaminergic transmission. At doses known to produce behavior al effects, LSD and mescaline (both 5-10 mg/kg)routinely enhanced sympathetic discharges in cats whether evoked reflexly by stimula-lion of spinal afferent fibers or directly by intraspinal stimulation of descending NE excitatory pathways The effects of LSD or mescaline could not be attributed to block of inhibitory 5-HT receptors although some blockade may have occurred. The drugs appear to stimulate excitatory NE receptors on SPGN or enhance transmission through the excitatory pathways. The results may partially explain the sympathetic stimulation caused by LSD and mescaline in man. However, psilocybin 0.4-0.8 mg/kg routinely depressed evoked sympathetic discharges, possibly by stimulation of inhibitory 5-HT receptors on SPGN.
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