Erowid References Database
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Sankar DVS, Kumbar M.
“Quantum chemical studies on drug actions: IV. correlation of substituent structures and anti-serotonin activity in lysergamide series”.
Res. Communications Chem. Pathol & Pharmacol.. 1974;7(2):259-274.
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Abstract
The correlation of quantum parameters of the lysergates with the antiserotonin activity of derivatives of LSD-25 is studied. Several hypotheses have been put forward relating the structures of LSD-25 and its congeners to the indolyl structure of tryptamines, and especially serotonin. The importance of side chain structures of the lysergates is stressed. The antiserotonin ac-tivity of several lysergate derivatives seems to be dependent on the total orbital energy, but not on the HOMO energy of the molecule. The logarithm of hallucinogeruc activity is related to the logarithm of antiserotonin activity. A high degree of electron-delocalization over the entire ring structure' is suggested, indicating possible resonance leading to effectual partial pi bonding between all four rings. The universal importance claimed for HOMO energy cannot be considered valid in the light of these studies. 18 references.
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| Notes # : (Nur Abstract aus: Psychopharmacology Abstracts vol. 12, no. 1, p. 91 (1975) vorhanden) |
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