Erowid References Database
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Anlezark G. Meldrum B.
“Blockade of Photically Induced Epilepsy by 'Dopamine' Agonist' Erect Alkaloids”.
Psychopharmacology. 1978;57(1):57-62.
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Abstract
The effect of the ergot alkaloids on p,hotically induced epilepsy was determined. Methods 13 Adolescent baboons were subjected to intermittent stroboscopic stimulation 10-30 min after i.v. administration of bromocriptine, ergocornine, LSD (Sandoz) or ergometrine and then t hourly intervals for up to. 6 hr. In 8 experiments, a subconvul-ant dose of 180-200 mg/kg allylglycine (Sigma-Chem,) was given 200 min before administration of LSD or ergocornine. Myoclonic responses were monitored. Results Ergocornine at 1-2 mg/kg produced marked autonomic and behavioral effects, slowed the EEG, and abolished myoclonic responses to intermittent photic stimulation (IPS). Ergometrine at 1 mg/kg activated the EEG and blocked the induction of myoclonic responses for 1-3 hr. Bromocriptine at 0.5-4 mg/kg did not consistently prevent myoclonic responses to IPS. After pretreatment with 180-200 mg/kg allylglycine, 0.1 mg/kg LSD retained the capacity to block myoclonic responses to IPS and 1 mg/kg ergocornine reduced such responses. At the same time, the convulsant effect of allylglycine was enhanced so that prolonged seizures sequences began 19-96 min after ergocornine administration. Conclusion The protective action of ergot alkaloids against epileptic responses induced by sensory stimulation is interpreted in terms of effects at several sites including dopaminergic and serotoninergic synapses.
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