Erowid References Database
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Anlezark G, Pycock C, Meldrum B.
“Ergot Alkaloids as Dopamine Agonists: Comparison in Two Rodent Models”.
Europ.J.Pharmacol.. 1976;387(2):295-302.
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Abstract
Ergot alkaloids were investigated as dopamine agonists in the rat. Methods Audiogenic seizures were produced in DBA/2 mice by means of a bell generating 109 dB at the level of the mouse and the ED -50 for the protective effects of i.p. apomorphine (Evans) (0.08-10 mg/kg), LSD-25 (Sandoz) (O.15-10 mg/kg), ergometrine (Sigma-Chem.) (0.4-20 mg/kg), ergocornine (Sandoz), methysergide (Sandoz) (5 and 20 mg/kg) piribedil (Servier), and 2-Br-a-ergocryptirle (CB154, Sandoz) (1-25 mg/kg) were determined. In addition the effect of haloperidol (Serenace, Searle) (0.5 mg/kg) on responses to apomorphine and ergocornine was tested. In a second study, the above agents were tested for induction of circling behavior in mice with unilateral destruction of 1 nigro-striatal dopamine pathway achieved by direct injection of 16 mcg 6-OHDA (Sigma) ínto 1 striatum. The order of potency against audiogenic seizures was apomorphine > ergocornine > bromocryptine > ergometrine LSD > methysergide > piribedil. The order of potency in the second study was apomorphine > ergometrine > ergocornine >bromocryptine > piribedil. Methysergide was ineffective and LSD produced only weak circling behavior even at doses > 1 mg/ kg. Pretreatment with haloperidol blocked the effects of dopamine agonists and ergot alkaloids in both studies.
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