Erowid References Database
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Biswas B, Ghos JJ.
“Delta 9 Tetrahydrocannabinol And Lysergic Acid Diethylamide: Comparative Changes In The Supraoptic And Paraventricular Neurosecretory Activities In Rat Hypothalamus”.
Anat. Anz.. 1975;138(4):324-331.
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Abstract
ACUTE DELTA 9 TETRAHYDROCANNABINOL (DELTA 9 THC, ADMINISTRATION (50 MG/KG, I.P.) PRODUCED ACCUMULATION OF STAINABLE NEUROSECRETORY MATERIALS (NSM) IN THE NEURAL LOBE INL] REGION WITH A CONCOMITANT DISPERSION OF STAINABLE NSM IN THE NEURONAL PERIKARYA OF HYPOTHALAMIC SUPRAOPTIC NUCLEUS {SON} AND PARAVENTRICULAR NUCLEUS {PVN} REGIONSE CHRONIC TREATMENT WITH DELTA 9 THC (10 MG/KG, 15 DAYS) PRODUCED MARKED ACCUMULATION OF NSM IN THE NL wITH MORE PROMINENT DEGRANULATION OF THE NEURONAL PERIKARYA OF SON AND PVN. ACUTE LSD TREATMENT (50 UEG/KG) CAUSED ACCUMULATION OF STAINABLE NSM IN THE NL REGION, WITH UNALTERED PERIKARYAL DISTRIBUTION PATTERN OF BOTH SON AND PVN; CHRONIC LSD TREATMENT (10 UEG/KG, 15 DAYS), ON THE OTHER HAND, CAUSED MARKED INCREASE OF NSM IN THE NEURONAL PERIKARYA OF SON AND PVN WITH NO PROMINENT ACCUMULATION IN THE NL. RESULTS INDICATED THAT CHRONIC EXPOSURE OF DELTA 9 THE LOWERED THE FUNCTIONAL ACTIVITY OF SON AND PVN NEURONS WHILE CHRONIC LSD TREATMENT STIMULATED THE HYPOTHALAMO NEUROHYPOPHYSEAL NEUROSECRETORY SYSTEM OF RATS.
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