Erowid References Database
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Brooks DC.
“The Effect of LSD Upon Spontaneous PGO Wave Activity and REM Sleep in the Cat”.
Neuropharmacology. 1975;14(11):847-57.
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Abstract
The effects of D-lysergic acid diethylamide (LSD) on spontaneous ponto-geniculo-occipital (PGO) wave activity and rapid eye movement (REM) sleep in the pentobarbital anesthetized cat was studied. Studies were made on 8 adult cats. Electrodes were implanted in the lateral geniculate nucleus and the marginal gyros. LSD was administered i.p. in doses of 2.5, 10, 25, 50, 100, 200, 400 and 800 mcg/kg. During the acute phase of LSD's action (90-120 min),the mcgO waves were identical to those which normally accompany eye movement in the alert cat (PGO-W). A pattern of 4-8/sec activity which is normally absent from the cortical EEG during arousal, began to dominate the recording in the intervals between mcgOW as the dose of LSD was increased to a maximum of 800 mcg/kg, The acute phase of drug action was followed by a prolonged period of slow wave, and a delay in the return of REM sleep and associated PGOREM waves. The results oppose the hypothesis that the hallucinogenic effect of LSD is due to the release of PGOREM into the state of wakefulness
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