Erowid References Database
|
Burov YV, Borisenko SA.
“Peculiarities of the Influence of Neurotropic Agents on the Hypothalamic Self -Stimulation”.
Byul.Éksp.Biol.Med.. 1976;81(1):43-45.
|
|
Abstract
The effects of various neurotropics on lateral hypothalamic self-stimulation in rats were studied. Male rats (250-350 g) were implanted with monopolar electrodes in the lateral hypothalamus under riembutal anesthesia (40 mg/kg i.p.). After recovery the rats were trained to self-stimulation through the electrode by pedal depression. The stimulatory current was varied, and the frequency of self-stimulation determined at the different current strengths (threshold, optimal and supra-optimal current strengths). The effects of 1 mg/kg phenamine (d-amphetamine), 10 mg/kg cocaine, 30 mg/kg caffeine, 1-3 mg/kg amizil (benactyzine), 0.5-1 mg/kg diazepam, 10-20 mg/kg meprobamate 3 mg/kg chlordiazopoxide, 3 mg/kg imizine (imipramine), 5-20 mg/kg phenobarbital, 3-10 mg/kg morphine and 0.05-0.5 mg/kg LSD-25 administered i.p. 30 min beforehand were studied in terms of frequency of self-stimulation at various current strengths. Results Phnamine, cocaine, caffeine, morphine and imipramine reduced the threshold of self-stimulation, increasing the frequency at threshold current strengths but decreasing the frequency at higher current strengths; these drugs appear to exert a direct stimulatory action or the positive reinforcement system. Meprobamate, diazepam and chlordiazopoxide had no effects on the threshold of self-stimulation but did increase the frequency of self-stimulation at all current strengths; these drugs appear to activate the positive reinforcement System in an indirect way by depressing the negative reinforcement system. Amizil and LSD-25 (at 0.1 mg/kg only) as well as phenobarbital decreased the threshold but tended to increase the frequency of self-stimulation at all current strengths.
|
| Notes # : (Nur Ring-Doc Referat vorhanden) |
| # |
| Submit Comment |
|
[
Cite HTML ]
