Erowid References Database
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CaLil HM.
“Screening Hallucinogenic Drugs. II. Systemic Study of Two Behavioral Tests”.
Psychopharmacology. 1978;56(1):87-92.
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Abstract
Two methods for screening hallucinogenic drugs were studied in the rat. 6 Male Wistar strain rats (250-300 g) were operantly conditioned to respond to a shock-light regimen. Responses were classified as premature if they occurred before the light, efficient if they occurred between light and shock and late if they occurred after the shock. 20 Male Wistar rats (260-300 g) were trained to discriminate a drug box from a control box at the end of a T-shaped maze, after treatment with delta-9-tetrahydrocannbainol (TC, 2.5 mg/kg, i.p.) and then tested with other drugs (i.p.). Results LSD-25 (0.2 mg/kg), mescalines (20 mg/kg),TC (5 mg/kg), psiolocin (3 mg/kg), psilocybin (2.0 mg/kg), harming (5 and 10 mg/kg) harmaline (10 and 15 mg/kg), chlorpromazine/l, 2 and 3 mg/kg), apomorphine (0.51 and 2 mg/kg), morphine (5 and 10 mg/kg), pentobarbital (5 and 10 mg/kg) and diazopam (1.25 mg/kg) produced an hallucinogenic profile by increasing premature and late responses in the operant conditioning test. However some hallucinogens also produced tranquilizer (i.e. increased late responses and reduced premature responses) and stimulant (i.e. increa sed premature and decreased late responses) responses profiles. Amphetamine (1.0 mg/kg) produced a stimulant profile only. In the maze test, all drugs except for LSD-25 (0.2 mg/kg), apomorphine (4 mg/kg), pentobarbital (5, 10 and 20 mg/kg) and phenoxybenzamine (20 mg/kg) were successfully discrminated. Pentobarbital (20 mg/kg) produced hypnosis, apomorphine (4 ma/ kg) produced stereotypy and phenoxybenzamine killed 3 rats. The maze test is recommended for the screening of hallucinogens
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