Erowid References Database
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Gallager DW, Aghajanian GK.
“Tricyclic Antidepressant Drugs: Attenuation of Excitatory Effects of d-Lysergic Acid Diethylamide (LSD) on Acoustic Startle Response”.
Life Sci.. 1977;20(7):1249-57.
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Abstract
The attenuation of the excitatory effects of LSD on acoustic startle response (ASR) was investigated. Methods Male 250-300 g albino Sprague Dawley rats were used through out. A 4000 Hz 90 msec 120 db tone was used as the startle stimulus and stabilimeters were used to determine the amplitude of the ARS. Each group of 5 rats was tested in 4 sessions using various combinations of pretreatment drugs. Sessions were con ducted at 2 day intervals and involved the presentation of 90 tones at a 20 sec intertone interval, immediately after i.p. 30 mcg/kg LSD. The pretreatment drug was given 15 min beforehand. Results Chlorimipramine, desipramine, imipramine, and chlordesi pramine at 5 mg/kg, all blocked the excitatory effects of LSD on the ASR. Chlorimipramine and desipramine caused an increase in brain LSD levels, however at 1-5 mg/kg both drugs were equipotent in blocking the LSD effect. Alpha-methyl-p-tyrosine did not block the LSD effect. Desipramine, imipramine, and chlordesi pramine alone but not chlorimipramine, increased ASR amplitude by 20-30%. The results were discussed in terms of the serotonin hypothesis of the action of hallucinogenic drugs on behavior.
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