Erowid References Database
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Davis M, Shears MH.
“Effects Of Lysergic Acid Diethylamide (LSD) On Temporal Recovery (pre Pulse Inhibition) Of The Acoustic Startle Response In The Rat”.
Pharm. Biochem. Behav.. 1975;3(5):861-868.
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Abstract
IN A SERIES OF EXPERIMENTS 40 UEG/KG D-LYSERGIC ACID DIETHYLAMIDE (LSD) AUGMENTED ACOUSTIC STARTLE AMPLITUDE IN RATS WHEN LONG INTERTONE INTERVALS (4, 8, 16, OR 32 SEC) WERE USED BUT NOT WHEN SHORT INTERSTIMULUS INTERVALS WERE USED (0.02, 0.1. 0.5, 1, OR 2 SEC). IN CONTRAST, 8 MG/KG D-AMPHETAMINE AUGMENTED STARTLE WHEN EITHER LONG OR SHORT INTERSTIMULUS INTERVALS WERE USED. THE RESULTS SUGGEST THAT LSD AUGMENTS STARTLE BY ACCELERATING THE DECAY OF PRE PULSE INHIBITION (TEMPORAL RECOVERY PROCESS) WHICH MAY BE ONE MECHANISM BY WHICH LSD CAN ALTER SENSORY PROCESSING.
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