Erowid References Database
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Dray A, Connors B, Fox PC, Hilmy H, Moore C, Somjen GG.
“Effects Of LSD On Unit Activity And Extracellular Potassium Responses In Cat Cortex During Visual Stimulation”.
Fed. Proc.. 1978;37(3):612.
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Abstract
In doses up to 50 mcg/kg i.v. LSD depressed the response to optical stimuli, and the unstimulated background firing of some neurons, but enhanced the activity of other neurons in the primary visual receiving area of cats. Larger doses were invariably depressant. To estimate average cell population behavior, transient elevations of extracellular potassium ([K+]o) were recorded with ion-selective microelectrodes Such [K+]o responses were selective for stimulus orientation and for direction of stimulus movement. 10 to 25 mcg/kg doses of LSD caused a depression of [K+]o transients, in 4 out of 5 experiments and an enhancement in one experiment. The difference between the responses to preferred and to non preferred stimuli decreased in 3 cases, and the preferred direction was reversed on one occasion. These changes may in part account for the distortion of visual percetion produced by LSD.
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| Notes # : Abstr., No. 2108 |
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