Erowid References Database
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Eliasson M, Meyerson BJ.
“The Effects of Lysergic Acid Diethylamide on Copulatory Behaviour in the Female Rat”.
Neuropharmacology. 1977;16(1):37-44.
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Abstract
The effects of LSD (Sandoz) on female rat copulatory behavior were studied Methods Female Sprague-Dawley rats, (270-330 g) were ovariectomized and as needed copulatory activity was induced by injection of estradiol benzoate (Organon, 10 mcg/kg) followed 2 days later by progesterone (Organon, 0.4 mg). In the groups of 10-12 female rats half received the test drugs and half a control injection. Studies were made of lordosis response, locomotor activity, vocalization, and habituation to the startle reaction The drugs were: LSD (0.1-0.5 mg/kg, i.p.), p-chlorophenyl alanine methylester.HCl (p-CPA; Haessle) and inhibitor, a-methyl-p-tyrosine methylester HCl (Q-MPT; Haessle). Results LSD gave a dose-related inhibition of the lordosis response, which was maximal at 10 min and was still significant at 30 min after 0.10 mg/kg, at 40 min after 0.25 mg/kg and at 90 min after 0.50 mg/kg. With p-CPA (350 mg/kg, i.p.) there was increased soliciting behavior and lordotic posture display was more intense. However, pretreatment with p-CPA caused a significantly prolonged inhibition of lordosis due to LSD as compared to the same dose of LSD given alone. Repeated administration of p-CPA when brain 5-HT levels were very low had no effect on the lordosis response. Lordotic responding reached 100% 40 min after injection of n-MPT (200 mg/kg, i.p.) and it decreased significantly the inhibitory effect of LSD. It was shown that inhibition of the lordosis response was not related to locomotor activity and there was a negative correlation between vocalization and the lordotic response. LSD inhibited habituation to the startle response and this was increased by pretreatment with p-CPA whilst a-MPT + LSD had no detectable effect on habituation to the startle response.
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