Erowid.org: Erowid Reference 3166 : Interaction Between Narcotic Antagonist (Naloxone) and Lysergic Acid Diethylamide (LSD) in the Rat : Fertziger AP, Fischer R

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Fertziger AP, Fischer R. “Interaction Between Narcotic Antagonist (Naloxone) and Lysergic Acid Diethylamide (LSD) in the Rat”. Psychopharmacology. 1977;54(3):313-14. <a name="ref">Fertziger AP, Fischer R.</a> <a href="/references/3166">"Interaction Between Narcotic Antagonist (Naloxone) and Lysergic Acid Diethylamide (LSD) in the Rat"</a> <i>Psychopharmacology</i>. 1977;54(3):313-14.
Text Abstract (this page) Full Text - English (194 K) Show Articles by Fertziger AP Fischer R Article IDs LSDID: 2914 Erowid RefID: 3166 PubMedID: unknown Collections Hofmann Collection MDMA Collection All References	Abstract A possible antagonistic interaction between LSD and naloxone was investigated in rats. LSD (375 mcg/kg) administration in rats (280-320 g) elicited a diphasic reaction consisting of a brief excitable period (up to 8 min) followed by a prolonged catalepsy (8 min-1 hr). While the cataleptic response was antagonized by a single injection of naloxone (Endo, 0.2 mg/kg. i.m. given 30 min after LSD administration), pretreatment with nalaxone shortened the excitable phase and potentiated the catalepsy.
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