Erowid References Database
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Fleisher LN.
“Hallucinogen-Induced Rotational Behavior in Rats”.
Dissertation Abstr.Intern.B.. 1978;38(7):2999.
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Abstract
Hallucinogen-induced rotational behavior in normal rats was studied. In addition, agents which interact with serotonergic and dopaminergic transmission were examined for their capacity to induce rotation and for possible interactions with LSD-induced rotation. LSD, mescaline and 5-methoxy-N N-dimethyltryptarnine (MDMT) induced dose-dependent rotation which was consistent in direction from wk to wk. Individual animals were found to rotate in the same direction when administered LSD, mescaline or MDMT, with 1 wk separating the administration of each hallucinogen. The direction of LSD-induced rotation for individual animals was found to be the same as d-amphetamine induced rotation, but not the same as apomorphine-induced rotation. Of the 3 postsynaptic serotonin antagonists (methysergide, cyproheptadine and 2-bromo-LSD) tested, only methysergide induced rotation. Methysergide-induced rotation was consistent in direction from wk to wk. and was in the same direction as LSD when the 2 drugs were given 1 wk apart. l-LSD the non-hallucinogenic enantiomer of d-LSD, induced weak rotation at the highest dose tested. It was approximately 6x less potent than d-LSD. LSD-induced rotation was blocked by pretreatment with a tyrosine hydroxylase inhibitor (Q-methyl-p-tyrosine) or a sub cataleptic dose of a dopamine receptor antagonist (haloperidol). Simultaneous administration of LSD and d-amphetamine induced rotation significantly greater than seen with d-amphetamine alone; a similar effect was observed following simultaneous administration of LSD and scopolamine. However, simultaneous administration of apomorphine and LSD induced rotation similar in magnitude to apomorphine alone. p-Chlorophenylalanine pretreatment increased the sensitivity of animals to the rotational effects of LSD. L-tryptophan pretreatment had no effect on LSD-induced rotation. The results of this investigation indicate that the mechanism by which these 3 hallucinogens induced rotation was consistent with an inhibitory action on the serotonin-containing midbrain raphe
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