Erowid References Database
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Fleisher LG.
“Stimulus properties of Hallucinogens in the Rat and the Squirrel Monkey”.
Dissertation Abstr.Intern.B. 1976;37(5):2184.
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Abstract
An investigation was undertaken to test the hypothesis that those pharmacologic properties which distinguish hallucinogens and nonhallucinogens in man are reflected in distinctive stimuli in rats and squirrel monkeys, Training sessions were conducted in which drug effects served either as SD, the treatment condition in which operant responding was reinforced, or as S-delta, the treatment condition in which responding was not reinforced, The efficacy of the drug treatments as discriminative stimuli was established by analyzing operant responding during tests in which responding had no programmed consequences (extinction), Comparison of the stimulus control produced by different drug treatments in the same subjects indicated whether or not the treatments produced stimuli which were distinctive, The hallucinogen, N,N-diethyltryptamine (Det), or its nonhallucinogenic analogue, 6-fluoro-N,N-diethyltryptamine (F-Det), could function as a discriminative stimulus in the rat, Rats could discriminate between the stimulus effects of equivalent doses of Det and F-Det when compared directly, 2-Brom-d-lysergic acid diethylamide (Bol), did not produce LSD-appropriate responding when tested in rats trained with LSD as a discriminative stimulus, Either pentobarbital or LSD could function as discriminative stimuli in the squirrel monkey, LSD did not produce pentobarbital-appropriate responding when tested in squirrel monkeys trained with pentobarbital as a discriminative stimulus. These results support the hypothesis that those pharmacologic properties which distinguish hallucinogens in man are reflected in distinctive stimuli in the rat and in the squirrel monkey.
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