Erowid References Database
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Green JP, Johnson CL, Weinstein H, Maayani S.
“Antagonism of histamine-activated adenylate cyclase in brain by D-lysergic acid diethylamide”.
Proc. Natl. Acad. Sci. (Wash). 1977;74(12):5697-5701.
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Abstract
D-Lysergic acid diethylamide and D-2-bromolysergic acid diethylamide are competitive antagonists of the histamine activation of adenylalc cyclase ATP pyrophphate-lyase (cyclizing)] in broken cell preparations of the hippocampus and cortex of guinea pig brain. The adenylate cyclase is linked to the histamine H2-receptor. Both D lysergic acid diethylamide and D-2-bromolysergic acid diethylamide show topological congruency with potent H2 antagonists. D-2-Bromolysergic acid diethylamide is 10 times more potent as an H2 antagonist than cimelidine, which has been the most potent H2 antagonist reported, and D-lysergic acid diethylamide is ahout equipotent to cimetidine. Blockade of H2 receptors could contribute to the effects of D-2-bromolysergic acid diethylamide and D-lysergic acid diethylamide.
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