Erowid References Database
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Holbrook L, Brown I.
“Antipsychotic Drugs Block LSD-Induced Disaggregation of Brain Polysomes.”.
Life Sci.. 1977;21(7):1037-43.
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Abstract
The effect of antipsychotic drugs on LSD-induced disaggre gation in brain polysomes was investigated. Rabbits were anesthetized and cortical bipolar electrodes were implanted. On the following day the rabbit was immobilized for recording EEGs before and after i.v. injection of 10 - 100 mcg/kg LSD (Sandoz). After 60 min the animal was killed and poly somes were prepared from the cerebral hemispheres, cerebellum and remaining brain stem. The resulting polysome pellet was dissolved in buffer and analyzed on linear sucrose gradients. When receptor blocking drugs were given they were injected i.v. 20 - 30 min prior to LSD, while pentobarbital (Nembutal, Abbott), ethanol (i.p.) and diphenylhydantoin (Dilantin, Parke-Davis) were given 5 10 min before LSD. 60 Min later animals were killed and brain polysomes analyzed. The degree of brain polysomes disaggregation increased as the dosage of LSD rose from 10, 25 and 100 mcg/kg. Cortical EEGs taken after LSD showed a decrease in EEG amplitude and increase in frequency. BOL-148 produced a complete blockage of the polysome shift. Haloperidol (Haldol, McNeil), chlorpromazine (Largactil, Poulenc), propranolol (Inderal, Ayerst), phentolamine (Rogitine; CIBA-Geigy) and pizotyline also prevented the LSD-induced polysome shift. Methysergide and cyproheptadine (Periactin, Merck-USA) potentiated LSD-induced polysome aggregation. A requirement for neuronal activity is suggested by the observation that the LSD-induced polysome shift is prevented when conductivity is depressed by ethanol, pentobarbital or diphenylhydantoin.
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