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Jacoby JH, Poulakos JJ.
“The actions of neuroleptic drugs and putative serotonin receptor antagonists on LSD and quipazine-induced reductions of brain 5-HIAA concentrations.”.
JPharm.Pharmacol.. 1977;29(12):771-73.
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Abstract
The actions of neuroleptic drugs and putative serotonin (5-HT) receptor antagonists on LSD and quipazine-induced reductions of rat brain 5-hydroxyindoleacetic acid (5-HIAA) were studied. Methods Male Sprague-Dawley rats were fasted overnight and were treated with antagonists i.p. 15 min before LSD (1 mg/kg, i.p.) and the animals were killed 60 min later. The brains were removed and assayed Łor 5-HT and 5-HIAA. The putative 5-HT receptor antagonists included i.p. methysergide (3 mg/kg), cyproheptadine (5 mg/kg), metergoline (5 mg/kg), cinanserin (25 mg/kg, propranolol (40 mg/kg), chlorpromazine (10 mg/kg), clozapine (10 mg/kg) or haloperidol (10 mg/kg). The effects of putative receptor antagonists on quipazine (10 mg/kg, i.p.) - induced impairment of brain 5-HIAA accumulation were studied after probenecid (200 mg/kg i.p.). Results LSD reduced brain 5-HIAA levels but there was no concomitant increase in brain 5-HT. The 5-HT-receptor antagonists methysergide, cyproheptadine, methergoline, cinanserin and propranolol did not prevent the reduction of 5-HIAA. Neuroleptic agents which exert a primary action by blocking dopamine receptors including chlorpromazine, haloperidol and clozapine inhibited the LSD-induced reduction of brain 5-HIAA levels. Haloperidol was the most potent in exerting this blockade. Quipazine reduced the accumulation of 5-HIAA after probenecid. Cryptoheptadine, methysergide, cinanserin and methergoline had no effect but haloperidol inhibited the quipazine-induced reduction of 5-HIAA accumulation. Chlorpromazine and clozapine were ineffective in blocking this action of quipazine.
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