Erowid References Database
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Kovacic B, Wang-Lu LJ, Ruffing D, Domino EF.
“Interactions of partial LSD analogs behavioral disrupting effects of LSD and DMT in the rat”.
European J. Pharmacol.. 1978;47:37-44.
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Abstract
Adult male Holtzman rats were trained to barpress on a schedule whereby every fourth press earned a reward of 0.01 m; of sugar-sweetened milk (FR4). After an i.p. injection of LSD (0.1 mg/kg) or DMT (3.2 or 10 mg/kg) such barpressing is abolished completely and resumed, usually within an hour, at a rate near the preinjection control rate of pressing. It continues at a steady, uninterrupted pace until the animals are removed from the operant chamber one-half hour later. A series of N,N-diethyluipecotamide derivatives were synthesized and tested for their ability to modify the disruptive effect of these hallucinogens. N,N-diedlylbutyramide (DBA) and 1-methyl 1,2,5,6-tetrahydropyridine-3-(N,N-diethylcarboxamide) (THPC) were also tested. Pretreatment with a single i.p. injection of any of these compounds (5Ð40 mg/kg) either had no effect on or else prolonged the duration of hallucinogen-induced cessation of barpressing.
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